Effect of posttransplant anti-HLA antibody on outcome of renal transplantation

Abstract

Pretransplant anti-HLA antibody has an impact on renal transplantation (RT) outcome. However, the role of posttransplant anti-HLA antibody in renal allograft outcome remains unclear. We conducted this study to determine whether posttransplant anti-HLA plays an important role in the outcome of renal allografts. Our investigation used a cross sectional design. Class I and II anti-HLA antibodies were obtained in 41 renal transplant patients. Patients had undergone either living-related (n = 15) or cadaveric (n = 26) RT. All patients had been transplanted for >6 months. The correlation of posttransplant class I and class II, anti-HLA antibodies with renal allograft function glomerular filtration rate (GFR) was analyzed. Patients displaying a GFR of >60 mL/min showed positive anti-HLA antibody status for class I (n = 2) and class II (n = 9). In contrast, those whose renal transplants showed a GFR <60 mL/min included three patients positive for HLA class I and 19 patients for HLA class II. Posttransplant class II anti-HLA antibody showed a negative correlation with GFR (r = -0.31, P =. 03). Preliminary results indicated that class II posttransplant anti-HLA antibody might be one mechanism of chronic renal allograft rejection and may confirm the important role of HLA matching in renal transplantation outcome.