Publication: Cyclopentenones, scaffolds for organic syntheses produced by the endophytic fungus mitosporic dothideomycete sp. LRUB20
Issued Date
2006-09-01
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ISSN
01633864
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2-s2.0-33750033691
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.69, No.9 (2006), 1351-1353
Suggested Citation
Porntep Chomcheon, Nongluksna Sriubolmas, Suthep Wiyakrutta, Nattaya Ngamrojanavanich, Narongsak Chaichit, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop Cyclopentenones, scaffolds for organic syntheses produced by the endophytic fungus mitosporic dothideomycete sp. LRUB20. Journal of Natural Products. Vol.69, No.9 (2006), 1351-1353. doi:10.1021/np060148h Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22988
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Title
Cyclopentenones, scaffolds for organic syntheses produced by the endophytic fungus mitosporic dothideomycete sp. LRUB20
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Abstract
Two new natural products, 2-hydroxymethyl-3-methylcyclopent-2-enone (1) (synthetically known) and cis-2-hydroxymethyl-3-methylcyclopentanone (2), and a known compound, asterric acid (3), were isolated from the endophytic fungus mitosporic Dothideomycete sp. LRUB20, which was isolated from the stem of the Thai medicinal plant Leea rubra. Compound 2 was separated and identified in the form of its 2,4-dinitrophenylhydrazone derivative (5). Compounds 1, 3, and hydrazone 5 exhibited mild antimycobacterial activity, both with MIC values of 200 μg/mL. Compounds 1, 3, and 4 were inactive (at 50 μg/mL) toward Vero, KB, NCI-H187, and BC cell lines. Hydrazone 5 showed only mild cytotoxicity against the Vero cell line with an IC50 value of 21.7 μg/mL; however, it was inactive toward KB, NCI-H187, and BC cell lines. Endophytic fungi may be a source for the production of building blocks for organic syntheses. © 2006 American Chemical Society and American Society of Pharmacognosy.