Publication: Exosome-inflammasome crosstalk and their roles in inflammatory responses
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Issued Date
2021-03-04
Resource Type
ISSN
18387640
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2-s2.0-85103433883
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Mahidol University
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SCOPUS
Bibliographic Citation
Theranostics. Vol.11, No.9 (2021), 4436-4451
Suggested Citation
Chadanat Noonin, Visith Thongboonkerd Exosome-inflammasome crosstalk and their roles in inflammatory responses. Theranostics. Vol.11, No.9 (2021), 4436-4451. doi:10.7150/THNO.54004 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/78355
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Title
Exosome-inflammasome crosstalk and their roles in inflammatory responses
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Abstract
Inflammasome is a complex of multiple proteins found in cytoplasm of the cells activated by infectious and/or non-infectious stimuli. This complex involves caspase-1 activation, leading to unconventional secretion of interleukin-1β (IL-1β) and IL-18 and inflammatory cascade. Exosome is the nanoscale membrane-bound extracellular vesicle that plays significant roles in intercellular communications by carrying bioactive molecules, e.g., proteins, RNAs, microRNAs (miRNAs), DNAs, from one cell to the others. In this review, we provide the update information on the crosstalk between exosome and inflammasome and their roles in inflammatory responses. The effects of inflammasome activation on exosomal secretion are summarized. On the other hand, the (dual) effects of exosomes on inhibiting and promoting inflammasome activation are discussed. Finally, perspectives on therapeutic roles of exosomes in human diseases and future direction of the research on exosome-inflammasome crosstalk are provided.