Publication: Polymyalgia rheumatica and risk of cerebrovascular accident: A systematic review and meta-analysis
Issued Date
2016-09-01
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ISSN
19984022
00283886
00283886
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2-s2.0-84988596365
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Mahidol University
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SCOPUS
Bibliographic Citation
Neurology India. Vol.64, No.5 (2016), 906-911
Suggested Citation
Patompong Ungprasert, Narat Srivali, Charat Thongprayoon Polymyalgia rheumatica and risk of cerebrovascular accident: A systematic review and meta-analysis. Neurology India. Vol.64, No.5 (2016), 906-911. doi:10.4103/0028-3886.190273 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/41202
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Title
Polymyalgia rheumatica and risk of cerebrovascular accident: A systematic review and meta-analysis
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Abstract
© 2016 Neurology India | Published by Wolters Kluwer - Medknow. Background: Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, have been linked to an increased risk of cerebrovascular accident (CVA), but the data on polymyalgia rheumatica (PMR) remains unclear. Materials and Methods: We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio, or standardized incidence ratio comparing the risk of CVA in patients with PMR versus non-PMR controls. Pooled risk ratio and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird. Results: Three retrospective cohort studies and one cross-sectional study were identified and included in the data analysis. We found a significantly elevated CVA risk in patients with PMR, with the pooled risk ratio of 1.87 (95% CI, 1.43-2.43). The statistical heterogeneity was high, with an I2 of 91%. Conclusions: Our study demonstrated a statistically significantly increased CVA risk among patients with PMR.