Publication: Study of DHPS and DHFR genes of Pneumocystis jirovecii in Thai HIV-infected patients
Issued Date
2008-06-01
Resource Type
ISSN
14602709
13693786
13693786
Other identifier(s)
2-s2.0-42349089614
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Medical Mycology. Vol.46, No.4 (2008), 389-392
Suggested Citation
Suradej Siripattanapipong, Saovanee Leelayoova, Mathirut Mungthin, Jeerapun Worapong, Peerapan Tan-Ariya Study of DHPS and DHFR genes of Pneumocystis jirovecii in Thai HIV-infected patients. Medical Mycology. Vol.46, No.4 (2008), 389-392. doi:10.1080/13693780701883722 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/18735
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Title
Study of DHPS and DHFR genes of Pneumocystis jirovecii in Thai HIV-infected patients
Abstract
The combination of trimethoprim-sulfamethoxazole is widely used for the prophylaxis and treatment of Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii. Many studies have shown that mutations in the drug target, the dihydropteroate synthase (DHPS) gene, are presumably involved with the failure of prophylaxis and treatment. We have analyzed dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) mutations in P. jirovecii isolates recovered from Thai patients. Out of 17 samples, 11.7% (2) of the DHPS gene contained a double mutation at codon 55 and codon 57, whereas out of 18 samples, 61.1% (11) of the DHFR genes contained the silent mutation at codon 104. In comparison to previous reports, we have found a higher number of DHFR mutations but a lower prevalence of DHPS mutations.