Publication: Altered expression of human monocyte Fc receptors in Plasmodium falciparum malaria
Issued Date
1984-08-02
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ISSN
00199567
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2-s2.0-0021266483
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Mahidol University
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SCOPUS
Bibliographic Citation
Infection and Immunity. Vol.44, No.3 (1984), 623-626
Suggested Citation
K. N. Ward, M. J. Warrell, J. Rhodes, S. Looareesuwan, N. J. White Altered expression of human monocyte Fc receptors in Plasmodium falciparum malaria. Infection and Immunity. Vol.44, No.3 (1984), 623-626. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/30610
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Title
Altered expression of human monocyte Fc receptors in Plasmodium falciparum malaria
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Abstract
The state of activation of human peripheral blood monocytes was examined by using a rosette assay that detects changes in Fc receptor expression. Monocytes from patients with uncomplicated Plasmodium falciparum malaria showed a significant increase in the number of rosettes relative to healthy controls. In addition, the monocytes from these patients were tested for their ability to phagocytose Candida albicans, but this ability did not differ from that of normal individuals. Finally, the monocytes from patients with cerebral malaria were also tested for Fc receptor expression. In contrast to the results from uncomplicated cases, the activity of the monocytes from these patients was no different from that of controls. We concluded that uncomplicated P. falciparum malaria caused an increase in monocyte Fc receptor expression which did not occur in cerebral malaria and that this difference in activation may be important in the pathogenesis of cerebral malaria.