Publication:
Tregitope-linked Refined Allergen Vaccines for Immunotherapy in Cockroach Allergy

dc.contributor.authorPannathee Prangtawornen_US
dc.contributor.authorUrai Chaisrien_US
dc.contributor.authorWatee Seesuayen_US
dc.contributor.authorKodchakorn Mahasongkramen_US
dc.contributor.authorNattawat Onlamoonen_US
dc.contributor.authorOnrapak Reamtongen_US
dc.contributor.authorAnchalee Tungtrongchitren_US
dc.contributor.authorNitaya Indrawattanaen_US
dc.contributor.authorWanpen Chaicumpaen_US
dc.contributor.authorNitat Sookrungen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherFaculty of Medicine, Siriraj Hospital, Mahidol Universityen_US
dc.date.accessioned2019-08-28T07:10:55Z
dc.date.available2019-08-28T07:10:55Z
dc.date.issued2018-12-01en_US
dc.description.abstract© 2018, The Author(s). Allergen-specific immunotherapy (AIT) facilitates long-term resolution of allergic morbidity resulting in reduced drug use and increased refractoriness to new sensitization. AIT effectiveness has been demonstrated in seasonal and perennial allergies, and insect stings. However, data and studies in AIT relative to cockroach (CR) allergy are relatively scarce. In this study, mice allergic to American CR (Periplaneta americana) were treated with a liposome (L)-entrapped vaccine made of mouse Tregitope289-Per a 9 of the CR, Tregitope167-Per a 9, or Per a 9 alone – or placebo. Allergic mice that received an individual vaccine intranasally had reduced Th2 response, reduced lung inflammation, and reduced respiratory tissue remodeling. However, only L-Tregitope289-Per a 9 and L-Tregitope167-Per a 9 induced expression of immunosuppressive cytokine genes (IL-10, TGF-β, and IL-35 for L-Tregitope289-Per a 9, and IL-10 and TGF-β for L-Tregitope167-Per a 9) and increment of idoleamine-2,3-dioxygenase 1 (IDO1), indicating that these vaccines caused allergic disease suppression and reversal of respiratory tissue remodeling via generation of regulatory lymphocytes. Liposome entrapped-recombinant Per a 9 (L-Per a 9) did not cause upregulation of immunosuppressive cytokine genes and IDO1 increment; rather, L-Per a 9 induced high expression of IFN-γ in lungs of treated mice, which resulted in mitigation of allergic manifestations. This study provides compelling evidence that both liposome-entrapped vaccines made of single refined major allergen alone and single refined major allergen linked with Tregitopes are effective for reducing allergen-mediated respiratory tissue inflammation and remodeling, but through different mechanisms.en_US
dc.identifier.citationScientific Reports. Vol.8, No.1 (2018)en_US
dc.identifier.doi10.1038/s41598-018-33680-9en_US
dc.identifier.issn20452322en_US
dc.identifier.other2-s2.0-85055073203en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/47465
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055073203&origin=inwarden_US
dc.subjectMultidisciplinaryen_US
dc.titleTregitope-linked Refined Allergen Vaccines for Immunotherapy in Cockroach Allergyen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055073203&origin=inwarden_US

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