Publication: The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites
Issued Date
2008-10-21
Resource Type
ISSN
10916490
00278424
00278424
Other identifier(s)
2-s2.0-55849142984
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Proceedings of the National Academy of Sciences of the United States of America. Vol.105, No.42 (2008), 16290-16295
Suggested Citation
Zbynek Bozdech, Sachel Mok, Guangan Hu, Mallika Imwong, Anchalee Jaidee, Bruce Russell, Hagai Ginsburg, Francois Nosten, Nicholas P J Day, Nicholas J. White, Jane M. Carlton, Peter R. Preiser The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites. Proceedings of the National Academy of Sciences of the United States of America. Vol.105, No.42 (2008), 16290-16295. doi:10.1073/pnas.0807404105 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/19924
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Title
The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites
Abstract
Plasmodium vivax causes over 100 million clinical infections each year. Primarily because of the lack of a suitable culture system, our understanding of the biology of this parasite lags significantly behind that of the more deadly species P. falciparum. Here, we present the complete transcriptional profile throughout the 48-h intraerythrocytic cycle of three distinct P. vivax isolates. This approach identifies strain specific patterns of expression for subsets of genes predicted to encode proteins associated with virulence and host pathogen interactions. Comparison to P. falciparum revealed significant differences in the expression of genes involved in crucial cellular functions that underpin the biological differences between the two parasite species. These data provide insights into the biology of P. vivax and constitute an important resource for the development of therapeutic approaches. © 2008 by The National Academy of Sciences of the USA.