Publication: Atypical femoral fractures: Epidemiology, etiology, and patient management
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Issued Date
2012-09-01
Resource Type
ISSN
17514266
17514258
17514258
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2-s2.0-84868341331
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Current Opinion in Supportive and Palliative Care. Vol.6, No.3 (2012), 348-354
Suggested Citation
Eve Donnelly, Anas Saleh, Aasis Unnanuntana, Joseph M. Lane Atypical femoral fractures: Epidemiology, etiology, and patient management. Current Opinion in Supportive and Palliative Care. Vol.6, No.3 (2012), 348-354. doi:10.1097/SPC.0b013e3283552d7d Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/14667
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Title
Atypical femoral fractures: Epidemiology, etiology, and patient management
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Abstract
Purpose of review To review the definition, epidemiology, and putative pathophysiology of atypical femoral fractures and propose strategies for the management of patients with atypical fractures as well as patients on long-term bisphosphonates without atypical fractures. Recent findings Recent epidemiologic evidence shows that the absolute incidence of atypical femoral fractures is small compared with the incidence of typical hip fractures. However, long-term bisphosphonate use may be an important risk factor for atypical fractures, and minimal additional antifracture benefit has been demonstrated for treatment durations longer than 5 years for patients with postmenopausal osteoporosis. This review gives advice to aid clinicians in the management of patients with incipient or complete atypical fractures. Summary Extremely limited evidence is available for how best to manage patients with atypical fractures. A comprehensive metabolic approach for the management of patients on long-term bisphosphonates will help to prevent oversuppression of bone remodeling that is implicated in the pathogenesis of these fractures. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.