Publication:
Genetic dissection of TrkB activated signalling pathways required for specific aspects of the taste system

dc.contributor.authorJuraj Koudelkaen_US
dc.contributor.authorJacqueline M. Hornen_US
dc.contributor.authorChinnavuth Vatanashevanopakornen_US
dc.contributor.authorLiliana Minichielloen_US
dc.contributor.otherUniversity of Edinburghen_US
dc.contributor.otherUniversity of Oxforden_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-11-09T02:33:48Z
dc.date.available2018-11-09T02:33:48Z
dc.date.issued2014-09-26en_US
dc.description.abstract© 2014 Koudelka et al.; licensee BioMed Central Ltd. Neurotrophin-4 (NT-4) and brain derived neurotrophic factor (BDNF) bind to the same receptor, Ntrk2/TrkB, but play distinct roles in the development of the rodent gustatory system. However, the mechanisms underlying these processes are lacking. Results: Here, we demonstrate, in vivo, that single or combined point mutations in major adaptor protein docking sites on TrkB receptor affect specific aspects of the mouse gustatory development, known to be dependent on BDNF or NT-4. In particular, mice with a mutation in the TrkB-SHC docking site had reduced gustatory neuron survival at both early and later stages of development, when survival is dependent on NT-4 and BDNF, respectively. In addition, lingual innervation and taste bud morphology, both BDNF-dependent functions, were altered in these mutants. In contrast, mutation of the TrkB-PLCγ docking site alone did not affect gustatory neuron survival. Moreover, innervation to the tongue was delayed in these mutants and taste receptor expression was altered. Conclusions: We have genetically dissected pathways activated downstream of the TrkB receptor that are required for specific aspects of the taste system controlled by the two neurotrophins NT-4 and BDNF. In addition, our results indicate that TrkB also regulate the expression of specific taste receptors by distinct signalling pathways. These results advance our knowledge of the biology of the taste system, one of the fundamental sensory systems crucial for an organism to relate to the environment.en_US
dc.identifier.citationNeural Development. Vol.9, No.1 (2014)en_US
dc.identifier.doi10.1186/1749-8104-9-21en_US
dc.identifier.issn17498104en_US
dc.identifier.other2-s2.0-84907410473en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/34188
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84907410473&origin=inwarden_US
dc.subjectMedicineen_US
dc.subjectNeuroscienceen_US
dc.titleGenetic dissection of TrkB activated signalling pathways required for specific aspects of the taste systemen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84907410473&origin=inwarden_US

Files

Collections