Publication: Diagnosis and Treatment of High-Grade Astrocytoma
Issued Date
2007-11-01
Resource Type
ISSN
07338619
Other identifier(s)
2-s2.0-35348962671
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Neurologic Clinics. Vol.25, No.4 (2007), 1111-1139
Suggested Citation
Sith Sathornsumetee, Jeremy N. Rich, David A. Reardon Diagnosis and Treatment of High-Grade Astrocytoma. Neurologic Clinics. Vol.25, No.4 (2007), 1111-1139. doi:10.1016/j.ncl.2007.07.004 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/24695
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Title
Diagnosis and Treatment of High-Grade Astrocytoma
Other Contributor(s)
Abstract
High-grade astrocytomas include the most common adult central nervous system (CNS) tumor, glioblastoma multiforme, and anaplastic astrocytoma-a highly aggressive cancer with short median survival despite maximal multimodality therapy. Diagnosis is by clinical and radiographic findings confirmed by histopathology. Standard-of-care therapy includes surgical resection, radiotherapy, and temozolomide. Nearly all patients who have high-grade astrocytomas develop tumor recurrence or progression after this multimodality treatment. Two treatment challenges are molecular/genetic heterogeneity of tumors and limited CNS tumor delivery. It is probable that targeted therapies will be most effective in combination with one another or with cytotoxic therapies. This article discusses diagnosis and current treatment of high-grade astrocytomas. © 2007 Elsevier Inc. All rights reserved.