Publication: Effects of prehospital adrenaline administration on out-of-hospital cardiac arrest outcomes: a systematic review and meta-analysis
7
Issued Date
2014
Resource Type
Language
eng
Rights
Mahidol University
Rights Holder(s)
BioMed Central
Bibliographic Citation
Critical Care. Vol. 18, (2014), 463
Suggested Citation
Pongsakorn Atiksawedparit, Sasivimol Rattanasiri, McEvoy, Mark, Graham, Colin A., Yuwares Sittichanbuncha, Ammarin Thakkinstian Effects of prehospital adrenaline administration on out-of-hospital cardiac arrest outcomes: a systematic review and meta-analysis. Critical Care. Vol. 18, (2014), 463. doi:10.1186/s13054-014-0463-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/2707
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Effects of prehospital adrenaline administration on out-of-hospital cardiac arrest outcomes: a systematic review and meta-analysis
Abstract
Introduction: The aim of this study was to conduct a systematic review and meta-analysis for determining the
effects of prehospital adrenaline administration on return of spontaneous circulation, hospital admission, survival to
discharge and discharge with cerebral performance category 1 or 2 in out-of-hospital cardiac arrest patients.
Methods: MEDLINE and Scopus databases were searched to identify studies reported to March 2014. Study
selection and data extraction were independently completed by two reviewers (PA and SR). The baseline
characteristics of each study and number of events were extracted. Risk ratios (RR) and 95% confidence interval (CI)
were estimated. Heterogeneity and publication bias were also explored.
Results: In total 15 studies were eligible and included in the study. Of 13 adult observational studies, four to eight
studies were pooled for each outcome. These yielded a total sample size that ranged from 2,381 to 421,459. A
random effects model suggested that patients receiving prehospital adrenaline were 2.89 times (95% CI: 2.36, 3.54)
more likely to achieve prehospital return of spontaneous circulation than those not administered adrenaline.
However, there were no significant effects on overall return of spontaneous circulation (RR = 0.93, 95% CI: 0.5, 1.74),
admission (RR = 1.05, 95% CI: 0.80, 1.38) and survival to discharge (RR = 0.69, 95% CI: 0.48, 1.00).
Conclusions: Prehospital adrenaline administration may increase prehospital return of spontaneous circulation, but
it does not improve overall rates of return of spontaneous circulation, hospital admission and survival to discharge.