Publication: The efficacy and tolerability of barnidipine hydrochloride in Thai patients with hypertension
Issued Date
2004-01-01
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ISSN
03000605
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2-s2.0-1642446583
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of International Medical Research. Vol.32, No.2 (2004), 185-200
Suggested Citation
Peera Buranakitjaroen, B. Koanantakul, M. Phoojaroenchanachai, C. Chawantanpipat The efficacy and tolerability of barnidipine hydrochloride in Thai patients with hypertension. Journal of International Medical Research. Vol.32, No.2 (2004), 185-200. doi:10.1177/147323000403200212 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/21246
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Title
The efficacy and tolerability of barnidipine hydrochloride in Thai patients with hypertension
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Abstract
This open-label, blinded study was performed to evaluate the efficacy and tolerability of barnidipine at a titrated dose of 10 - 15 mg once daily for 8 weeks in the treatment of essential hypertension in 40 Thai patients. 'Office' blood pressure (BP) and 24-h ambulatory BP measurements were recorded. A systolic BP/diastolic BP (SBP/DBP) reduction of 18.0 ± 13.6/9.1 ± 6.6 mmHg was obtained. The full response rate among patients with systolic and diastolic hypertension was 63% using either SBP or DBP criteria, and 54% using both SBP and DBP criteria. One of the two patients with isolated systolic hypertension had a full response, and the BP in two of the three patients with isolated diastolic hypertension was normalized. The trough-to-peak ratio and smoothness index for SBP/DBP were acceptable (0.76 ± 0.63/0.55 ± 0.26 and 1.2 ± 0.4/1.2 ± 0.3, respectively). In conclusion, once-daily barnidipine monotherapy provides effective 24-h BP control and is generally well tolerated in ambulatory patients.