Publication: Magnetic particles for in vitro molecular diagnosis: From sample preparation to integration into microsystems
4
Issued Date
2017-10-01
Resource Type
ISSN
18734367
09277765
09277765
Other identifier(s)
2-s2.0-85021141985
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Mahidol University
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SCOPUS
Bibliographic Citation
Colloids and Surfaces B: Biointerfaces. Vol.158, (2017), 1-8
Suggested Citation
Tienrat Tangchaikeeree, Duangporn Polpanich, Abdelhamid Elaissari, Kulachart Jangpatarapongsa Magnetic particles for in vitro molecular diagnosis: From sample preparation to integration into microsystems. Colloids and Surfaces B: Biointerfaces. Vol.158, (2017), 1-8. doi:10.1016/j.colsurfb.2017.06.024 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/41764
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Title
Magnetic particles for in vitro molecular diagnosis: From sample preparation to integration into microsystems
Abstract
© 2017 Elsevier B.V. Colloidal magnetic particles (MPs) have been developed in association with molecular diagnosis for several decades. MPs have the great advantage of easy manipulation using a magnet. In nucleic acid detection, these particles can act as a capture support for rapid and simple biomolecule separation. The surfaces of MPs can be modified by coating with various polymer materials to provide functionalization for different applications. The use of MPs enhances the sensitivity and specificity of detection due to the specific activity on the surface of the particles. Practical applications of MPs demonstrate greater efficiency than conventional methods. Beyond traditional detection, MPs have been successfully adopted as a smart carrier in microfluidic and lab-on-a-chip biosensors. The versatility of MPs has enabled their integration into small single detection units. MPs-based biosensors can facilitate rapid and highly sensitive detection of very small amounts of a sample. In this review, the application of MPs to the detection of nucleic acids, from sample preparation to analytical readout systems, is described. State-of-the-art integrated microsystems containing microfluidic and lab-on-a-chip biosensors for the nucleic acid detection are also addressed.