Publication: Fungicide Xylaria sp. BCC 1067 extract induces reactive oxygen species and activates multidrug resistance system in Saccharomyces cerevisiae
| dc.contributor.author | Pichayada Somboon | en_US |
| dc.contributor.author | Attaporn Poonsawad | en_US |
| dc.contributor.author | Songsak Wattanachaisaereekul | en_US |
| dc.contributor.author | Laran T. Jensen | en_US |
| dc.contributor.author | Masakazu Niimi | en_US |
| dc.contributor.author | Supapon Cheevadhanarak | en_US |
| dc.contributor.author | Nitnipa Soontorngun | en_US |
| dc.contributor.other | King Mongkut s University of Technology Thonburi | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Chulalongkorn University | en_US |
| dc.date.accessioned | 2018-12-21T08:00:27Z | |
| dc.date.accessioned | 2019-03-14T08:03:53Z | |
| dc.date.available | 2018-12-21T08:00:27Z | |
| dc.date.available | 2019-03-14T08:03:53Z | |
| dc.date.issued | 2017-04-01 | en_US |
| dc.description.abstract | © 2017 Future Medicine Ltd. Aim: To investigate antifungal potential of Xylaria sp. BIOTEC culture collection (BCC) 1067 extract against the model yeast Saccharomyces cerevisiae. Materials & methods: Antifungal property of extract, reactive oxygen species levels and cell survival were determined, using selected deletion strains. Results: Extract showed promising antifungal effect with minimal inhibitory concentration100and minimal fungicidal concentration of 500 and 1000 mg/l, respectively. Strong synergy was observed with fractional inhibitory concentration index value of 0.185 for the combination of 60.0 and 0.5 mg/l of extract and ketoconazole, respectively. Extract-induced intracellular reactive oxygen species levels in some oxidant-prone strains and mediated plasma membrane rupture. Antioxidant regulator Yap1, efflux transporter Pdr5 and ascorbate were pivotal to protect S. cerevisiae from extract cytotoxicity. Conclusion: Xylaria sp. BCC 1067 extract is a potentially valuable source of novel antifungals. | en_US |
| dc.identifier.citation | Future Microbiology. Vol.12, No.5 (2017), 417-440 | en_US |
| dc.identifier.doi | 10.2217/fmb-2016-0151 | en_US |
| dc.identifier.issn | 17460921 | en_US |
| dc.identifier.issn | 17460913 | en_US |
| dc.identifier.other | 2-s2.0-85017559134 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/42839 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85017559134&origin=inward | en_US |
| dc.subject | Immunology and Microbiology | en_US |
| dc.title | Fungicide Xylaria sp. BCC 1067 extract induces reactive oxygen species and activates multidrug resistance system in Saccharomyces cerevisiae | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85017559134&origin=inward | en_US |