Publication: Factors associated with multidrug-resistant tuberculosis (MDR-TB) in Bhutan: A nationwide case-control study
Issued Date
2020-01-01
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ISSN
19326203
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2-s2.0-85088812203
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Mahidol University
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SCOPUS
Bibliographic Citation
PloS one. Vol.15, No.7 (2020), e0236250
Suggested Citation
Chador Tenzin, Natkamol Chansatitporn, Tashi Dendup, Tandin Dorji, Karma Lhazeen, Dorji Tshering, Thinley Pelzang Factors associated with multidrug-resistant tuberculosis (MDR-TB) in Bhutan: A nationwide case-control study. PloS one. Vol.15, No.7 (2020), e0236250. doi:10.1371/journal.pone.0236250 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/57650
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Title
Factors associated with multidrug-resistant tuberculosis (MDR-TB) in Bhutan: A nationwide case-control study
Abstract
BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is a growing public health concern globally. In Bhutan, the rates of MDR-TB are high. Data on the risk factors of MDR-TB that can help inform policies are limited in Bhutan. This study aimed to determine the risk factors associated with MDR-TB. METHODS: A nationwide unmatched case-control study was conducted that included 79 MDR-TB cases and 118 controls. Data was collected by trained health workers through interviews using a structured questionnaire. Logistic regression analysis was performed to identify the risk factors associated with MDR-TB. RESULTS: The mean age of the participants was 32.4 and 33.7 years among the cases and the controls, respectively. In the multivariate analysis, the odds of having MDR-TB was higher among those who slept for less than 9 hours a day (AOR: 2.77, 95%CI: 1.11-6.92), frequently travelled in public transport (AOR: 2.96, 95% CI: 1.36-6.48), and had previous TB treatment (AOR: 5.90, 95%CI: 2.55-13.64). A greater number of rooms was also marginally associated with odds of having MDR-TB. CONCLUSIONS: The findings suggest previous TB treatment, inadequate sleep duration, and travelling by public transport to be the risk factors associated with having MDR-TB in Bhutan. Intensification of early case detection, strengthening directly observed treatment strategy, improving treatment adherence, and increasing awareness can help control the rising MDR-TB epidemic.