Publication: A prophylactic approach for bone marrow transplantation from a hepatitis B surface antigen-positive donor
dc.contributor.author | Abhasnee Sobhonslidsuk | en_US |
dc.contributor.author | Artit Ungkanont | en_US |
dc.contributor.other | Mahidol University | en_US |
dc.date.accessioned | 2018-08-24T02:09:40Z | |
dc.date.available | 2018-08-24T02:09:40Z | |
dc.date.issued | 2007-02-21 | en_US |
dc.description.abstract | It has been accepted that bone marrow transplantation (BMT) is the only curative therapeutic option for certain hematologic malignancies. The southeast Asia region is an endemic area of hepatitis B virus (HBV) infection; thus, BMT using a hepatitis B surface antigen (HBsAg)-positive donor is occasionally unavoidable. Organ transplantation using a HBsAg-positive donor can lead to post-transplantation de novo HBV infection and severe HBV-related hepatitis if no effective prophylactic measures are taken prior to and after transplantation. In this report, a four-level approach was designed for a patient with chronic myeloid leukemia, beginning with a booster HBV vaccination before performing BMT with a HBsAg-positive donor. Prior to BMT, the HBV viral load of the donor was reduced to an undetectable level by antiviral therapy. After BMT, hepatitis B immunoglobulin was administered intramuscularly for 1 wk together with a long-term antiviral drug, lamivudine. One year after discontinuation of lamivudine, the patient is still free of HBV infection. © 2007 The WJG Press. All rights reserved. | en_US |
dc.identifier.citation | World Journal of Gastroenterology. Vol.13, No.7 (2007), 1138-1140 | en_US |
dc.identifier.doi | 10.3748/wjg.v13.i7.1138 | en_US |
dc.identifier.issn | 10079327 | en_US |
dc.identifier.other | 2-s2.0-34047102950 | en_US |
dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/24985 | |
dc.rights | Mahidol University | en_US |
dc.rights.holder | SCOPUS | en_US |
dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34047102950&origin=inward | en_US |
dc.subject | Medicine | en_US |
dc.title | A prophylactic approach for bone marrow transplantation from a hepatitis B surface antigen-positive donor | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication | |
mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34047102950&origin=inward | en_US |