Publication:
A prophylactic approach for bone marrow transplantation from a hepatitis B surface antigen-positive donor

dc.contributor.authorAbhasnee Sobhonslidsuken_US
dc.contributor.authorArtit Ungkanonten_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-08-24T02:09:40Z
dc.date.available2018-08-24T02:09:40Z
dc.date.issued2007-02-21en_US
dc.description.abstractIt has been accepted that bone marrow transplantation (BMT) is the only curative therapeutic option for certain hematologic malignancies. The southeast Asia region is an endemic area of hepatitis B virus (HBV) infection; thus, BMT using a hepatitis B surface antigen (HBsAg)-positive donor is occasionally unavoidable. Organ transplantation using a HBsAg-positive donor can lead to post-transplantation de novo HBV infection and severe HBV-related hepatitis if no effective prophylactic measures are taken prior to and after transplantation. In this report, a four-level approach was designed for a patient with chronic myeloid leukemia, beginning with a booster HBV vaccination before performing BMT with a HBsAg-positive donor. Prior to BMT, the HBV viral load of the donor was reduced to an undetectable level by antiviral therapy. After BMT, hepatitis B immunoglobulin was administered intramuscularly for 1 wk together with a long-term antiviral drug, lamivudine. One year after discontinuation of lamivudine, the patient is still free of HBV infection. © 2007 The WJG Press. All rights reserved.en_US
dc.identifier.citationWorld Journal of Gastroenterology. Vol.13, No.7 (2007), 1138-1140en_US
dc.identifier.doi10.3748/wjg.v13.i7.1138en_US
dc.identifier.issn10079327en_US
dc.identifier.other2-s2.0-34047102950en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/24985
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34047102950&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleA prophylactic approach for bone marrow transplantation from a hepatitis B surface antigen-positive donoren_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34047102950&origin=inwarden_US

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