Publication: Immune dysfunction in HIV-seronegative, Cryptococcus gattii meningitis
Issued Date
2007-03-01
Resource Type
ISSN
01634453
Other identifier(s)
2-s2.0-33847053609
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Infection. Vol.54, No.3 (2007)
Suggested Citation
Annemarie E. Brouwer, Asna A. Siddiqui, Maartje I. Kester, Kim C.E. Sigaloff, Adul Rajanuwong, Saran Wannapasni, Wirongrong Chierakul, Thomas S. Harrison Immune dysfunction in HIV-seronegative, Cryptococcus gattii meningitis. Journal of Infection. Vol.54, No.3 (2007). doi:10.1016/j.jinf.2006.10.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24979
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Title
Immune dysfunction in HIV-seronegative, Cryptococcus gattii meningitis
Abstract
The pathophysiology of meningitis caused by Cryptococcus gattii in apparently immunocompetent individuals remains unclear. We measured multiple cytokines in CSF from a HIV-seronegative, apparently immunocompetent, Thai patient with C. gattii meningitis, over the first 2 weeks of antifungal therapy. Levels of proinflammatory IFN-γ, TNF-α, and IL-6 were very low compared to patients with HIV-related Cryptococcus neoformans meningitis and of IL-10 very high. While patients with C. gattii meningitis may be a heterogeneous group, these data suggest in this case a maladapted immune response to cryptococcal exposure had allowed progression to clinical cryptococcal disease. © 2006 The British Infection Society.