Publication:
Synthesis of gem-difluoromethylenated spiro-γ-butyrolactones by employing PhSCF<inf>2</inf>Si(CH<inf>3</inf>)<inf>3</inf>as a gem-difluoromethylenating agent

Issued Date

2013-10-01

Resource Type

Article

ISSN

10990690
1434193X

DOI

10.1002/ejoc.201300998

Other identifier(s)

2-s2.0-84885597753

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

European Journal of Organic Chemistry. No.30 (2013), 6844-6858

Suggested Citation

Adisak Chatupheeraphat, Darunee Soorukram, Chutima Kuhakarn, Patoomratana Tuchinda, Vichai Reutrakul, Chaveng Pakawatchai, Saowanit Saithong, Manat Pohmakotr Synthesis of gem-difluoromethylenated spiro-γ-butyrolactones by employing PhSCF<inf>2</inf>Si(CH<inf>3</inf>)<inf>3</inf>as a gem-difluoromethylenating agent. European Journal of Organic Chemistry. No.30 (2013), 6844-6858. doi:10.1002/ejoc.201300998 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/31510

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Title

Synthesis of gem-difluoromethylenated spiro-γ-butyrolactones by employing PhSCF<inf>2</inf>Si(CH<inf>3</inf>)<inf>3</inf>as a gem-difluoromethylenating agent

Author(s)

Adisak Chatupheeraphat
 Darunee Soorukram
 Chutima Kuhakarn
 Patoomratana Tuchinda
 Vichai Reutrakul
 Chaveng Pakawatchai
 Saowanit Saithong
 Manat Pohmakotr

Other Contributor(s)

Mahidol University
 Prince of Songkla University

Abstract

PhSCF2TMS was utilized as a useful gem-difluoromethylene building block for the synthesis of gem-difluoromethylenated spiro-γ-butyrolactones. The radical cyclization of γ-alkenyl- γ-gem-difluoro(phenylsulfanyl)methyl-γ-butyrolactones provided gem-difluoromethylenated spiro-γ-butyrolactones. PhSCF2TMS (TMS = trimethylsilyl) is utilized as a gem-difluoromethylenating agent for the synthesis of gem-difluoromethylenated spiro-γ-butyrolactones. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keyword(s)

Chemistry

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/31510

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