Publication: Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, actinoallomurus fulvus MK10-036
Issued Date
2015-02-20
Resource Type
ISSN
15237052
15237060
15237060
Other identifier(s)
2-s2.0-84923379773
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Organic Letters. Vol.17, No.4 (2015), 864-867
Suggested Citation
Yuki Inahashi, Masato Iwatsuki, Aki Ishiyama, Atsuko Matsumoto, Tomoyasu Hirose, Jun Oshita, Toshiaki Sunazuka, Watanalai Panbangred, Yoko Takahashi, Marcel Kaiser, Kazuhiko Otoguro, Satoshi O'mura Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, actinoallomurus fulvus MK10-036. Organic Letters. Vol.17, No.4 (2015), 864-867. doi:10.1021/ol5037216 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35498
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, actinoallomurus fulvus MK10-036
Abstract
© 2015 American Chemical Society. Five new anti-trypanosomal macrolides, actinoallolides A-E (1-5), were discovered from the cultured broth of Actinoallomurus fulvus MK10-036. The structures of the actinoallolides, including absolute stereochemistry, were elucidated by a combination of spectroscopic analyses and a series of chemical derivatization studies. Actinoallolide A showed the most potent and selective in vitro anti-trypanosomal activity without cytotoxicity. A new class of promising lead compounds was identified for the development of drugs for both sleeping sickness and Chagas disease.