Publication: Effect of process variables on the microencapsulation of vitamin A palmitate by gelatin-acacia coacervation
Issued Date
2001-09-12
Resource Type
ISSN
03639045
Other identifier(s)
2-s2.0-0034863075
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Drug Development and Industrial Pharmacy. Vol.27, No.6 (2001), 561-566
Suggested Citation
Varaporn Buraphacheep Junyaprasert, Ampol Mitrevej, Nuttanan Sinchaipanid, Prapaporn Boonme, Dale Eric Wurster Effect of process variables on the microencapsulation of vitamin A palmitate by gelatin-acacia coacervation. Drug Development and Industrial Pharmacy. Vol.27, No.6 (2001), 561-566. doi:10.1081/DDC-100105181 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26445
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Effect of process variables on the microencapsulation of vitamin A palmitate by gelatin-acacia coacervation
Other Contributor(s)
Abstract
Microcapsules of vitamin A palmitate were prepared by gelatin-acacia complex coacervation. The effects of colloid mixing ratio, core-to-wall ratio, hardening agent, concentration of core solution, and drying method on the coacervation process and the properties of the microcapsules were investigated. The microcapsules of vitamin A palmitate were prepared using different weight ratios of gelatin and acacia, that is, 2:3, 1:1, and 3:2 under controlled conditions. The other factors studied were 1:1, 1:2, and 1:3 core-to-wall ratios; 30, 60, and 120 min of hardening time; 2, 5, and 10 ml of formaldehyde per 280 g of coacervation system as a hardening agent; and 30%, 40%, and 50% w/w vitamin A palmitate in corn oil as a core material. The drying methods used were air drying, hot air at 40°C, and freezedrying. The results showed that spherical microcapsules were obtained for all conditions except for 30 min of hardening time, which did not result in microcapsules. The optimum conditions for free-flowing microcapsules with a high percentage of entrapped drug were 1:1 gelatin-to-acacia ratio and 1:2 core-to-wall ratio when hardening with 2 ml formaldehyde for 60 min and using 40% w/w vitamin A palmitate in corn oil as the core concentration. In addition, drying the microcapsules by freeze-drying provided microcapsules with excellent appearance.