Publication: p53 gene mutations in non-small cell lung cancer from Thai patients
Issued Date
1999-03-01
Resource Type
ISSN
01252208
Other identifier(s)
2-s2.0-0033088913
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.82, No.3 (1999), 250-255
Suggested Citation
Songsak Petmitr, Siriwan Makthiengtrong, Pantap Sutinont, Panata Migasena p53 gene mutations in non-small cell lung cancer from Thai patients. Journal of the Medical Association of Thailand. Vol.82, No.3 (1999), 250-255. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/25669
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Title
p53 gene mutations in non-small cell lung cancer from Thai patients
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Abstract
Paraffin embedded tissues from twenty-two Thai patients with non-small cell lung cancer were studied for p53 gene mutations in exon 5 to 8 using polymerase chain reaction and single-stranded conformation polymorphism (PCR-SSCP) followed by thermal cycle sequencing. Results showed that point mutations in this region of p53 gene were present in 3 cases. One harboured the base change from GAC to AAC at codon 281, changing amino acid from aspartic acid to asparagine, whilst the other two cases were transversion of AAA (lysine) to ACA (threonine) at codon 292. All subjects with p53 mutation had a past history of tobacco smoking.