Publication: Inhibition of Naja kaouthia venom activities by plant polyphenols
Issued Date
2005-03-21
Resource Type
ISSN
03788741
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2-s2.0-14644401059
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Ethnopharmacology. Vol.97, No.3 (2005), 527-533
Suggested Citation
Pimolpan Pithayanukul, Pakatip Ruenraroengsak, Rapepol Bavovada, Narumol Pakmanee, Rutt Suttisri, Suwipa Saen-Oon Inhibition of Naja kaouthia venom activities by plant polyphenols. Journal of Ethnopharmacology. Vol.97, No.3 (2005), 527-533. doi:10.1016/j.jep.2004.12.013 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/17170
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Title
Inhibition of Naja kaouthia venom activities by plant polyphenols
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Abstract
Plant polyphenols from the aqueous extracts of Pentace burmanica, Pithecellobium dulce, Areca catechu and Quercus infectoria were tested for their inhibitory activities against Naja kaouthia (NK) venom by in vitro neutralization method. The first three extracts could completely inhibit the lethality of the venom at 4 LD50concentration and the venom necrotizing activity at the minimum necrotizing dose while also inhibited up to 90% of the acetylcholinesterase activity of NK venom at much lower tannin concentrations than that of Quercus infectoria. The ED50of plant tannins in inhibiting NK venom activities varied according to condensed tannins and their content in the extracts. Molecular docking of the complexes between α-cobratoxin and either hydrolysable or condensed tannins at their lowest energetic conformations were proposed. The anti-venom activities of these plant polyphenols by selectively blocking the nicotinic acetylcholine receptor and non-selectively by precipitation of the venom proteins were suggested. © 2005 Elsevier Ireland Ltd. All rights reserved.