Publication: Bioactive tetrahydrofuran lignans from roots, stems, leaves and twigs of Anogeissus rivularis
Issued Date
2021-06-01
Resource Type
ISSN
18736971
0367326X
0367326X
Other identifier(s)
2-s2.0-85103663190
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Fitoterapia. Vol.151, (2021)
Suggested Citation
Wannee Sukbangnop, Anowar Hosen, Sakchai Hongthong, Chutima Kuhakarn, Patoomratana Tuchinda, Suppisak Chaturonrutsamee, Sariyarach Thanasansurapong, Radeekorn Akkarawongsapat, Jitra Limthongkul, Chanita Napaswad, Arthit Chairoungdua, Kanoknetr Suksen, Narong Nuntasaen, Vichai Reutrakul Bioactive tetrahydrofuran lignans from roots, stems, leaves and twigs of Anogeissus rivularis. Fitoterapia. Vol.151, (2021). doi:10.1016/j.fitote.2021.104885 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/78961
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Title
Bioactive tetrahydrofuran lignans from roots, stems, leaves and twigs of Anogeissus rivularis
Abstract
Four previously undescribed tetrahydrofuran lignans, named anorisols A−D (1–4) and fourteen known compounds (5–18) were isolated from the roots, stems, leaves and twigs of Anogeissus rivularis. The chemical structures were elucidated on the basis of their spectroscopic data and by comparison with the literature data. The absolute configurations of 1–4 were established by comparison of the experimental ECD spectra with the calculated ECD spectra. Some isolated compounds were evaluated for their cytotoxic activity as well as anti-HIV-1 activity employing reverse transcriptase (RT) and syncytium reduction assays using the ΔTat/RevMC99 virus in 1A2 cell line systems. Compound 6 displayed the most potent activity in syncytium inhibition assay with effective concentration at 50% (EC50) value of 13.3 μM (SI >3.0). In the reverse transcriptase assay, compound 1 exhibited moderate activity with IC50 value of 213.9 μM.