Publication:
Association of IL1B -31C/T and IL1RA variable number of an 86-bp tandem repeat with dengue shock syndrome in Thailand

dc.contributor.authorAreerat Sa-Ngasangen_US
dc.contributor.authorJun Ohashien_US
dc.contributor.authorIzumi Nakaen_US
dc.contributor.authorSurapee Anantapreechaen_US
dc.contributor.authorPathom Sawanpanyalerten_US
dc.contributor.authorJintana Patarapotikulen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThailand Ministry of Public Healthen_US
dc.contributor.otherUniversity of Tsukubaen_US
dc.contributor.otherThe Food and Drug Administration, Thailand Ministry of Public Healthen_US
dc.date.accessioned2018-11-09T02:36:06Z
dc.date.available2018-11-09T02:36:06Z
dc.date.issued2014-07-01en_US
dc.description.abstractBackground. Dengue patients present a range of symptoms: dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS). It is not clear whether this variability is due to their genetic background. Here we tested polymorphisms of interleukin 1 beta (IL1B) and interleukin 1 receptor antagonist (IL1RA) genes for association with DSS in the Thai population. Methods. Polymorphisms of IL1B -31C/T (rs1143627) and IL1RA 86-base-pair tandem repeat were analyzed in 871 patients (DF = 384, DHF = 413, and DSS = 74). Results. IL1B -31C and IL1RA 2/4 genotype were associated with DSS (IL1B -31C: DSS vs DHF: P = .0061, odds ratio [OR, 95% confidence interval {CI}], 3.49 [1.36-8.95]; DSS vs DF: P = .027, OR [95% CI], 2.81 [1.12-7.06]; IL1RA 2/4: DSS vs DHF: P = .017, OR [95% CI], 1.94 [1.12-3.40]; DSS vs DF: P = .024, OR [95% CI], 1.90 [1.07-3.4]). No difference was found between DF and DHF. Logistic regression analysis revealed that IL1B -31C and IL1RA 2/4 genotypes were each independently associated with DSS. Conclusions. Patients with IL1B -31C carrier, or IL1RA 2/4 genotype carry a risk for DSS, implying that IL1B may play a role in pathogenesis of DSS.en_US
dc.identifier.citationJournal of Infectious Diseases. Vol.210, No.1 (2014), 138-145en_US
dc.identifier.doi10.1093/infdis/jiu042en_US
dc.identifier.issn15376613en_US
dc.identifier.issn00221899en_US
dc.identifier.other2-s2.0-84904294294en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/34230
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904294294&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleAssociation of IL1B -31C/T and IL1RA variable number of an 86-bp tandem repeat with dengue shock syndrome in Thailanden_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904294294&origin=inwarden_US

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