Publication:
Carboplatin-based regimen in pediatric intracranial germ-cell tumors (IC-GCTs): Effectiveness and ototoxicity

Issued Date

2020-03-19

Resource Type

Article

ISSN

20542585
20542577

DOI

10.1093/nop/npz043

Other identifier(s)

2-s2.0-85084003815

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Neuro-Oncology Practice. Vol.7, No.2 (2020), 202-210

Suggested Citation

Rasin Worawongsakul, Nongnuch Sirachainan, Apimid Rojanawatsirivej, Atthaporn Boongird, Arunee Singhsnaeh, Thiti Swangsilpa, Mantana Dhanachai, Putipun Puataweepong, Rawee Ruangkanchanasetr, Samart Pakakasama, Usanarat Anurathapan, Duantida Songdej, Pongpak Pongphitcha, Chaiyos Khongkhatithum, Ake Hansasuta, Nintita Sripaiboonkij Thokanit, Apasri Lusawat, Sarunya Yuthagovit, Samasuk Thammachantha, Danupon Muangruk, Suradej Hongeng Carboplatin-based regimen in pediatric intracranial germ-cell tumors (IC-GCTs): Effectiveness and ototoxicity. Neuro-Oncology Practice. Vol.7, No.2 (2020), 202-210. doi:10.1093/nop/npz043 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/56278

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Title

Carboplatin-based regimen in pediatric intracranial germ-cell tumors (IC-GCTs): Effectiveness and ototoxicity

Author(s)

Rasin Worawongsakul
 Nongnuch Sirachainan
 Apimid Rojanawatsirivej
 Atthaporn Boongird
 Arunee Singhsnaeh
 Thiti Swangsilpa
 Mantana Dhanachai
 Putipun Puataweepong
 Rawee Ruangkanchanasetr
 Samart Pakakasama
 Usanarat Anurathapan
 Duantida Songdej
 Pongpak Pongphitcha
 Chaiyos Khongkhatithum
 Ake Hansasuta
 Nintita Sripaiboonkij Thokanit
 Apasri Lusawat
 Sarunya Yuthagovit
 Samasuk Thammachantha
 Danupon Muangruk
 Suradej Hongeng

Other Contributor(s)

Faculty of Medicine, Ramathibodi Hospital, Mahidol University
 Prasat Neurological Institute
 Loei Hospital

Abstract

© 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Neuro-Oncology and the European Association of Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. Background: Induction chemotherapy with carboplatin followed by radiotherapy has been used for many years for treating intracranial germ-cell tumors (IC-GCTs) in Thailand. The objective of this study was to assess treatment outcomes, focusing on survival and ototoxicity. Methods: The outcomes of all patients with IC-GCT treated at Ramathibodi Hospital and the Prasat Neurological Institute between 2000 and 2017 were reviewed and analyzed, including all patient characteristics and treatment modalities. Five-year overall survival (OS) and event-free survival (EFS) were analyzed using the Kaplan-Meier method, and factors affecting survival were compared using the log-rank test. Results: Fifty-three patients age 1-14 years (median, 11 years) were included in this study. The median follow-up time was 63 months. The 5-year EFS and OS rates were 94.3% and 96.2% for all patients, respectively. No statistical difference in OS or EFS was observed between the data of recipients in the carboplatin-based and historical cisplatin-based therapies in our institutes. Concerning radiotherapy, omission of radiotherapy or focal irradiation results in worse long-term survival outcomes, but reduction in dose of radiotherapy to less than 40 Gy did not cause any negative impact on survival rates. Furthermore, carboplatin was associated with lower rates of hearing loss than cisplatin (5.7% vs 87.5%). Conclusions: Induction chemotherapy with carboplatin-based regimens was associated with excellent survival rates and low ototoxicity in patients with IC-GCT. Radiotherapy should be given to all patients with a minimal volume equivalent to whole-ventricular radiotherapy, during which doses of lower than 40 Gy can be effectively used.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/56278

Collections

Scopus 2020