Publication: Effects of surfactant on release characteristics of clonidine hydrochloride from ethylcellulose film
Issued Date
1999-03-11
Resource Type
ISSN
03639045
Other identifier(s)
2-s2.0-0032975386
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Drug Development and Industrial Pharmacy. Vol.25, No.3 (1999), 373-377
Suggested Citation
Narong Sarisuta, Ruedee Saowakontha, Charassri Ruangsuksriwong Effects of surfactant on release characteristics of clonidine hydrochloride from ethylcellulose film. Drug Development and Industrial Pharmacy. Vol.25, No.3 (1999), 373-377. doi:10.1081/DDC-100102185 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25347
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Effects of surfactant on release characteristics of clonidine hydrochloride from ethylcellulose film
Other Contributor(s)
Abstract
The effects of Tween 80 (polysorbate 80) and Span 80 (sorbitan monooleate) surfacrants on release characteristics of clonidine hydrochloride from ethylcellulose 10 and 20 cps matrix films containing castor oil as a plasticizer were investigated. The release rates of drug from these films in water at 37°C were found to increase with the addition of surfactant, which was highest for the film prepared from ethylcellulose 20 cps with Tween 80. The experimental values of the cumulative amount of drug released were found to conform to the solution matrix model. The calculated values of the cumulative amount of clonidine hydrochloride released using the experimentally determined diffusion coefficients were also found to be in good agreement with the observed values.