Publication: Effects of the organophosphate insecticide, monocrotophos, on acetylcholinesterase activity in the nile tilapia fish (Oreochromis niloticus) brain
Issued Date
1995-05-01
Resource Type
ISSN
15736903
03643190
03643190
Other identifier(s)
2-s2.0-0029060796
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Neurochemical Research. Vol.20, No.5 (1995), 587-591
Suggested Citation
Wipawan Thangnipon, Wipa Thangnipon, Pinsuda Luangpaiboon, Supranee Chinabut Effects of the organophosphate insecticide, monocrotophos, on acetylcholinesterase activity in the nile tilapia fish (Oreochromis niloticus) brain. Neurochemical Research. Vol.20, No.5 (1995), 587-591. doi:10.1007/BF01694540 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17240
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Title
Effects of the organophosphate insecticide, monocrotophos, on acetylcholinesterase activity in the nile tilapia fish (Oreochromis niloticus) brain
Abstract
The neurotoxic effects of monocrotophos on the brain of the nile tilapia fish (Oreochromis niloticus) were examined, using a static bioassay under laboratory conditions. By probit analysis the 96 h LC50value of monocrotophos was 4.9 mg/l. After 96 h exposure to acute levels of monocrotophos, the brain acetylcholinesterase (AChE) activity decreased progressively as the concentration of monocrotophos increased. In addition, four weeks following transfer to toxicant-free water after exposure to 1 mg monocrotophos, nile tilapia fish brain regained 95% of control AChE activity. The results indicate that inhibition of AChE activity in fish exposed to monocrotophos may serve as an indicator of hazard due to application of this chemical in the natural environment. © 1995 Plenum Publishing Corporation.