Publication: Carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in a Filipino with positive HLA-B75 serotype
Issued Date
2018-01-01
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1757790X
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2-s2.0-85050278876
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Mahidol University
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SCOPUS
Bibliographic Citation
BMJ Case Reports. Vol.2018, (2018)
Suggested Citation
Francis Capule, Pramote Tragulpiankit, Surakameth Mahasirimongkol, Nuanjun Wichukchinda, Jiraphun Jittikoon, Lara Theresa Alentajan-Aleta, Jay V. James Barit, Josephine Casanova-Gutierrez, Leonor Cabral-Lim, Jose Paciano Baltazar Reyes, Francisca Roa, Katrina Faith San Gabriel, Catherine Lynn Silao Carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in a Filipino with positive HLA-B75 serotype. BMJ Case Reports. Vol.2018, (2018). doi:10.1136/bcr-2018-225028 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/47197
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Title
Carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in a Filipino with positive HLA-B75 serotype
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Abstract
© BMJ Publishing Group Limited 2018. No commercial re-use. See rights and permissions. Published by BMJ. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two related mucocutaneous disorders with different severities. Although the incidence is low, SJS and TEN are life-threatening and predominantly drug-induced conditions. There is a strong relationship between the HLA-B∗1502 allele and carbamazepine-induced SJS and TEN in different Southeast Asian populations. Here, we report a case of Filipino with SJS/TEN overlap probably induced by carbamazepine. The condition was treated with hydrocortisone followed by prednisone. The HLA-B∗1502 allele was not found in this case. The patient tested positive for the HLA-B75 serotype, suggesting that carbamazepine-induced SJS/TEN may be serotype specific. Establishing the genotype before initiation of the drug may be advantageous for some patients and will aid physicians in determining the optimal drug therapy. Prevention of adverse drug reactions (ADR) may be done if pharmacists and other healthcare professionals work as a multidisciplinary ADR team to ensure that safe medication practices are realised.