Publication: Effect of nedocromil sodium on the immediate response to antigen challenge in asthmatic patients
Issued Date
1986-01-01
Resource Type
ISSN
13652222
09547894
09547894
Other identifier(s)
2-s2.0-85004809747
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical & Experimental Allergy. Vol.16, No.2 (1986), 129-134
Suggested Citation
P. YOUNGCHAIYUD, T. B. LEE Effect of nedocromil sodium on the immediate response to antigen challenge in asthmatic patients. Clinical & Experimental Allergy. Vol.16, No.2 (1986), 129-134. doi:10.1111/j.1365-2222.1986.tb00756.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/9763
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Title
Effect of nedocromil sodium on the immediate response to antigen challenge in asthmatic patients
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Abstract
In this double‐blind placebo controlled crossover study the protective effect of nedocromil sodium against bronchial allergen challenge was evaluated in ten asthmatic patients. Single doses of 0.5, 1.0 and 2.0 mg nedocromil sodium, administered as a pressurized aerosol 3 hr prior to challenge, were each significantly more effective than placebo in inhibiting allergen‐induced bronchoconstriction. The 1.0 and 2.0 mg doses of the active drug were significantly more effective than the 0.5 mg dose. No significant difference was demonstrated between the 1.0 and 2.0 mg doses. Duration of protection beyond 3 hr was not tested. The results suggest that nedocromil sodium may be a potentially useful therapeutic agent and is worthy of further evaluation for the treatment of reversible obstructive airways disease. Copyright © 1986, Wiley Blackwell. All rights reserved