Publication: Depot‐medroxyprogesterone acetate (dmpa) and risk of edometrial cancer
Issued Date
1991-01-01
Resource Type
ISSN
10970215
00207136
00207136
Other identifier(s)
2-s2.0-0025826644
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Cancer. Vol.49, No.2 (1991), 186-190
Suggested Citation
Suporn Silpisornkosol, Tieng Pardthaisong, Virote Sahapong, Choti Theetranont, Banpot Boosiri, Supawat Chutivongse, Pramuan Virutamasen, Chansuda Wongsrchanalai, Sermsri Sindhvananda, Suporn Koetsawang, Daungdao Rachawat, Amom Koetsawang, F. A. Langley, David B. Thomas Study Coordinator, Roberta M. Ray, Elizabeth A. Noonan, Janet L. Stanford, Karin A. Rosenblatt, Susan Holck, Timothy M.M. Farley, David B. Thomas, Roberta M. Ray Depot‐medroxyprogesterone acetate (dmpa) and risk of edometrial cancer. International Journal of Cancer. Vol.49, No.2 (1991), 186-190. doi:10.1002/ijc.2910490207 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22014
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Title
Depot‐medroxyprogesterone acetate (dmpa) and risk of edometrial cancer
Author(s)
Suporn Silpisornkosol
Tieng Pardthaisong
Virote Sahapong
Choti Theetranont
Banpot Boosiri
Supawat Chutivongse
Pramuan Virutamasen
Chansuda Wongsrchanalai
Sermsri Sindhvananda
Suporn Koetsawang
Daungdao Rachawat
Amom Koetsawang
F. A. Langley
David B. Thomas Study Coordinator
Roberta M. Ray
Elizabeth A. Noonan
Janet L. Stanford
Karin A. Rosenblatt
Susan Holck
Timothy M.M. Farley
David B. Thomas
Roberta M. Ray
Tieng Pardthaisong
Virote Sahapong
Choti Theetranont
Banpot Boosiri
Supawat Chutivongse
Pramuan Virutamasen
Chansuda Wongsrchanalai
Sermsri Sindhvananda
Suporn Koetsawang
Daungdao Rachawat
Amom Koetsawang
F. A. Langley
David B. Thomas Study Coordinator
Roberta M. Ray
Elizabeth A. Noonan
Janet L. Stanford
Karin A. Rosenblatt
Susan Holck
Timothy M.M. Farley
David B. Thomas
Roberta M. Ray
Abstract
This is a report of results from a case‐control study of the relationship of the long‐acting progestational contraceptive, depot‐medroxyprogesterone acetate (DMPA) to risk of endometrial carcinoma. Prior use of DMPA and information on known and suspected risk factors for endometrial cancer were ascertained in personal interviews with 122 women with histologically confirmed disease and 939 controls selected from 2 hospitals in Bangkok and 1 in Chiang Mai, Thailand. Based on 3 exposed cases and 84 exposed controls, the relative risk of endometrial cancer was estimated to be 0.21 (95% confidence interval = 0.06,0.79) in women who had ever used DMPA (but who had not first used DMPA in the year prior to diagnosis). All 3 exposed cases had also received estrogens pre‐menopausally. Exposure to such estrogens enhanced risk of endometrial cancer and reduced the apparent protective effect of DMPA. Although based on small numbers of exposed women, the protective effect of DMPA appeared to last for at least 8 years after cessation of use. The reduction in risk of endometrial cancer is at least as great for DMPA as for combined oral contraceptives. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company
