Publication: 4-(Phenylsulfanyl) butan-2-one attenuates the inflammatory response induced by amyloid-β oligomers in retinal pigment epithelium cells
Issued Date
2021-01-01
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ISSN
16603397
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2-s2.0-85099114917
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Mahidol University
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SCOPUS
Bibliographic Citation
Marine Drugs. Vol.19, No.1 (2021)
Suggested Citation
Peeraporn Varinthra, Shun Ping Huang, Supin Chompoopong, Zhi Hong Wen, Ingrid Y. Liu 4-(Phenylsulfanyl) butan-2-one attenuates the inflammatory response induced by amyloid-β oligomers in retinal pigment epithelium cells. Marine Drugs. Vol.19, No.1 (2021). doi:10.3390/md19010001 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/78985
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Title
4-(Phenylsulfanyl) butan-2-one attenuates the inflammatory response induced by amyloid-β oligomers in retinal pigment epithelium cells
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Abstract
Age-related macular degeneration (AMD) is a progressive eye disease that causes irreversible impairment of central vision, and effective treatment is not yet available. Extracellular accumulation of amyloid-beta (Aβ) in drusen that lie under the retinal pigment epithelium (RPE) has been reported as one of the early signs of AMD and was found in more than 60% of Alzheimer’s disease (AD) patients. Extracellular deposition of Aβ can induce the expression of inflammatory cytokines such as IL-1β, TNF-α, COX-2, and iNOS in RPE cells. Thus, finding a compound that can effectively reduce the inflammatory response may help the treatment of AMD. In this research, we investigated the anti-inflammatory effect of the coral-derived compound 4-(phenylsulfanyl) butan-2-one (4-PSB-2) on Aβ1-42 oligomer (oAβ1-42 ) added to the human adult retinal pigment epithelial cell line (ARPE-19). Our results demonstrated that 4-PSB-2 can decrease the elevated expressions of TNF-α, COX-2, and iNOS via NF-κB signaling in ARPE-19 cells treated with oAβ1-42 without causing any cytotoxicity or notable side effects. This study suggests that 4-PSB-2 is a promising drug candidate for attenuation of AMD.