Publication: Abrogation of ALK5 in hepatic stellate cells decreases hepatic fibrosis and ameliorates liver damage in mice following treatment with thioacetamide
dc.contributor.author | Somyoth Sridurongrit | en_US |
dc.contributor.author | Chen Ke | en_US |
dc.contributor.author | Wanthita Kongphat | en_US |
dc.contributor.author | Arnon Pudgerd | en_US |
dc.contributor.author | Chanyatip Suwannasing | en_US |
dc.contributor.other | Mahidol University | en_US |
dc.date.accessioned | 2019-08-28T07:13:23Z | |
dc.date.available | 2019-08-28T07:13:23Z | |
dc.date.issued | 2018-03-01 | en_US |
dc.description.abstract | © 2018, Prince of Songkla University. All rights reserved. While transforming growth factor-β (TGF-β) is known to be a key inducer of hepatic stellate cell (HSC) activation during liver fibrosis but it is unclear which TGF-β receptor is required for this HSC-mediated fibrogenesis. Here, we report that abrogation of TGF-β type I receptor ALK5 in HSC activation led to reduced collagen deposition and a decreased number of myofibroblasts in livers of mutant mice lacking ALK5 in HSC (Alk5/GFAP-Cre mice) following thioacetamide (TAA) exposure. The reduced fibrosis was accompanied by decreased expression of HSC activation markers in livers. In addition, Alk5/GFAP-Cre mice exhibited decreased immune cell infiltration and reduced production of inflammatory cytokines. Associated with reduced fibrosis and inflammation, amelioration of liver injury was observed in Alk5/GFAP-Cre mice after TAA treatment. In conclusion, our results indicated that TGF-β signaling via ALK5 in HSC enhanced liver fibrogenesis and inflammation led to amplification of hepatic injury in mice exposed to TAA. | en_US |
dc.identifier.citation | Songklanakarin Journal of Science and Technology. Vol.40, No.2 (2018), 314-320 | en_US |
dc.identifier.doi | 10.14456/sjst-psu.2018.31 | en_US |
dc.identifier.issn | 01253395 | en_US |
dc.identifier.other | 2-s2.0-85048337768 | en_US |
dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/47528 | |
dc.rights | Mahidol University | en_US |
dc.rights.holder | SCOPUS | en_US |
dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048337768&origin=inward | en_US |
dc.subject | Multidisciplinary | en_US |
dc.title | Abrogation of ALK5 in hepatic stellate cells decreases hepatic fibrosis and ameliorates liver damage in mice following treatment with thioacetamide | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication | |
mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048337768&origin=inward | en_US |