Publication:
Abrogation of ALK5 in hepatic stellate cells decreases hepatic fibrosis and ameliorates liver damage in mice following treatment with thioacetamide

dc.contributor.authorSomyoth Sridurongriten_US
dc.contributor.authorChen Keen_US
dc.contributor.authorWanthita Kongphaten_US
dc.contributor.authorArnon Pudgerden_US
dc.contributor.authorChanyatip Suwannasingen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2019-08-28T07:13:23Z
dc.date.available2019-08-28T07:13:23Z
dc.date.issued2018-03-01en_US
dc.description.abstract© 2018, Prince of Songkla University. All rights reserved. While transforming growth factor-β (TGF-β) is known to be a key inducer of hepatic stellate cell (HSC) activation during liver fibrosis but it is unclear which TGF-β receptor is required for this HSC-mediated fibrogenesis. Here, we report that abrogation of TGF-β type I receptor ALK5 in HSC activation led to reduced collagen deposition and a decreased number of myofibroblasts in livers of mutant mice lacking ALK5 in HSC (Alk5/GFAP-Cre mice) following thioacetamide (TAA) exposure. The reduced fibrosis was accompanied by decreased expression of HSC activation markers in livers. In addition, Alk5/GFAP-Cre mice exhibited decreased immune cell infiltration and reduced production of inflammatory cytokines. Associated with reduced fibrosis and inflammation, amelioration of liver injury was observed in Alk5/GFAP-Cre mice after TAA treatment. In conclusion, our results indicated that TGF-β signaling via ALK5 in HSC enhanced liver fibrogenesis and inflammation led to amplification of hepatic injury in mice exposed to TAA.en_US
dc.identifier.citationSongklanakarin Journal of Science and Technology. Vol.40, No.2 (2018), 314-320en_US
dc.identifier.doi10.14456/sjst-psu.2018.31en_US
dc.identifier.issn01253395en_US
dc.identifier.other2-s2.0-85048337768en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/47528
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048337768&origin=inwarden_US
dc.subjectMultidisciplinaryen_US
dc.titleAbrogation of ALK5 in hepatic stellate cells decreases hepatic fibrosis and ameliorates liver damage in mice following treatment with thioacetamideen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048337768&origin=inwarden_US

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