Publication: Angiotensin receptor neprilysin inhibitor as a novel antihypertensive drug: Evidence from Asia and around the globe
dc.contributor.author | Donna S.H. Lin | en_US |
dc.contributor.author | Tzung Dau Wang | en_US |
dc.contributor.author | Peera Buranakitjaroen | en_US |
dc.contributor.author | Chen Huan Chen | en_US |
dc.contributor.author | Hao Min Cheng | en_US |
dc.contributor.author | Yook Chin Chia | en_US |
dc.contributor.author | Apichard Sukonthasarn | en_US |
dc.contributor.author | Jam Chin Tay | en_US |
dc.contributor.author | Boon Wee Teo | en_US |
dc.contributor.author | Yuda Turana | en_US |
dc.contributor.author | Ji Guang Wang | en_US |
dc.contributor.author | Kazuomi Kario | en_US |
dc.contributor.other | Siriraj Hospital | en_US |
dc.contributor.other | Sunway University | en_US |
dc.contributor.other | Jichi Medical University | en_US |
dc.contributor.other | Shanghai Jiao Tong University School of Medicine | en_US |
dc.contributor.other | National Taiwan University Hospital | en_US |
dc.contributor.other | National Yang-Ming University Taiwan | en_US |
dc.contributor.other | Universitas Katolik Indonesia Atma Jaya | en_US |
dc.contributor.other | Department of Medicine | en_US |
dc.contributor.other | Universiti Malaya | en_US |
dc.contributor.other | Veterans General Hospital-Taipei | en_US |
dc.contributor.other | Tan Tock Seng Hospital | en_US |
dc.contributor.other | Chiang Mai University | en_US |
dc.date.accessioned | 2022-08-04T11:00:08Z | |
dc.date.available | 2022-08-04T11:00:08Z | |
dc.date.issued | 2021-03-01 | en_US |
dc.description.abstract | Hypertension is a worldwide epidemic that continues to grow, with a subset of patients responding poorly to current treatment available. This is especially relevant in Asia, which constitutes 61% of the global population. Hypertension in Asia is a unique entity that is often salt-sensitive, nocturnal, and systolic predominant. Sacubitril/valsartan is a first-in-class angiotensin receptor neprilysin inhibitor that was first used in heart failure with reduced ejection fraction. Sacubitril inhibits neprilysin, a metallopeptidase that degrades natriuretic peptides (NPs). NPs exert sympatholytic, diuretic, natriuretic, vasodilatory, and insulin-sensitizing effects mostly via cyclic guanosine monophosphate (cGMP)-mediated pathways. As an antihypertensive agent, sacubitril/valsartan has outperformed angiotensin II receptor type 1 blockers (ARBs), with additional reductions of office systolic blood pressures ranging between 5 and 7 mmHg, in multiple studies in Asia and around the globe. The drug was well tolerated even in the elderly or those with chronic kidney disease. Its mechanisms of actions are particularly attractive for treatment of hypertension in Asia. Sacubitril/valsartan offers a novel, dual class, single-molecule property that may be considered as first-line antihypertensive therapy. Further investigations are needed to validate its safety for long-term use and to explore other potentials such as in the management of insulin resistance and obesity, which often coexist with hypertension in Asia. | en_US |
dc.identifier.citation | Journal of Clinical Hypertension. Vol.23, No.3 (2021), 556-567 | en_US |
dc.identifier.doi | 10.1111/jch.14120 | en_US |
dc.identifier.issn | 17517176 | en_US |
dc.identifier.issn | 15246175 | en_US |
dc.identifier.other | 2-s2.0-85097424703 | en_US |
dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/78423 | |
dc.rights | Mahidol University | en_US |
dc.rights.holder | SCOPUS | en_US |
dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85097424703&origin=inward | en_US |
dc.subject | Medicine | en_US |
dc.title | Angiotensin receptor neprilysin inhibitor as a novel antihypertensive drug: Evidence from Asia and around the globe | en_US |
dc.type | Review | en_US |
dspace.entity.type | Publication | |
mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85097424703&origin=inward | en_US |