Publication: MECHANISM OF CATECHOLAMINE ANTAGONISM IN RAT HEART PRODUCED BY PILOCARPINE AND RELATED DRUGS
Issued Date
1974-01-01
Resource Type
ISSN
14765381
00071188
00071188
Other identifier(s)
2-s2.0-0016259980
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
British Journal of Pharmacology. Vol.52, No.1 (1974), 97-100
Suggested Citation
C. SADAVONGVIVAD, P. SANVARINDA, JUTAMAAD SATAYAVIVAD MECHANISM OF CATECHOLAMINE ANTAGONISM IN RAT HEART PRODUCED BY PILOCARPINE AND RELATED DRUGS. British Journal of Pharmacology. Vol.52, No.1 (1974), 97-100. doi:10.1111/j.1476-5381.1974.tb09692.x Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/10726
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Title
MECHANISM OF CATECHOLAMINE ANTAGONISM IN RAT HEART PRODUCED BY PILOCARPINE AND RELATED DRUGS
Other Contributor(s)
Abstract
High concentrations of pilocarpine and methacholine consistently lowered the potencies of a series of adrenoceptor agonists as shown by displacement of complete cumulative dose‐effect curves for their positive chronotropic action on rat isolated atria. The order of potency of the agonists was characteristic of β‐adrenoceptor activation and this was converted to the type which characterizes α‐adrenoceptor activation when pilocarpine was present. Propranolol effectively blocked the adrenoceptor agonists in the presence of pilocarpine and phentolamine abolished the antagonistic actions of pilocarpine. Atropine, which by itself did not affect the action of the adrenoceptor agonists, abolished both the bradycardia and antagonism produced by pilocarpine. It is concluded that pilocarpine antagonizes adrenoceptor agonists by muscarinic cholinoceptor activation without involving classical adrenoceptors. 1974 British Pharmacological Society