Publication: Opisthorchis viverrini infection in Thailand: Symptoms and signs of infection–a population-based study
Issued Date
1994-01-01
Resource Type
ISSN
18783503
00359203
00359203
Other identifier(s)
2-s2.0-0028032222
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Mahidol University
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SCOPUS
Bibliographic Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.88, No.5 (1994), 561-564
Suggested Citation
Swangjai Pungpak, Kobsiri Chalermrut, Tranakchit Harinasuta, Chaisin Viravan, P. F. Schelp, Asel Hempfling, Peter Schlattmann, Danai Bunnag Opisthorchis viverrini infection in Thailand: Symptoms and signs of infection–a population-based study. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.88, No.5 (1994), 561-564. doi:10.1016/0035-9203(94)90164-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/9597
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Title
Opisthorchis viverrini infection in Thailand: Symptoms and signs of infection–a population-based study
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Abstract
A population-based study of the clinical, laboratory and ultrasonographic findings in patients suffering from mild or moderate opisthorchiasis in Prachinburi province, Thailand was conducted in 1990–1992. The effectiveness of treatment with praziquantel at 40 mg/kg body weight was evaluated. After treatment, a longlasting, marked improvement in the well-being of the study group was observed. Symptoms common in opisthorchiasis infection decreased in intensity and the clinical response showed total or partial remission in 98% of all cases studied. Total and direct bilirubin concentrations decreased significantly and remained low up to the end of the follow-up period of 2 years, indicating a reduction in cholestasis. Also, white blood cell counts decreased initially, which can be interpreted as a reduction in inflammation intensity. No relationship was found between intensity of infection and age or clinical findings, Population-based treatment of opisthorchiasis appears to have had a significant impact on public health in north-east Thailand. However, it is also evident that drug therapy alone will not solve the opisthorchiasis problem, as indicated by the reinfection rate of almost 10% at the end of the study. © 1994 Oxford University Press.