Publication: Inhibition of Hepatocarcinogenesis in Mice by Dietary Methyl Donors Methionine and Choline
1
Issued Date
1990-01-01
Resource Type
ISSN
15327914
01635581
01635581
Other identifier(s)
2-s2.0-0025205193
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nutrition and Cancer. Vol.14, No.3-4 (1990), 175-181
Suggested Citation
Paul M. Newberne Inhibition of Hepatocarcinogenesis in Mice by Dietary Methyl Donors Methionine and Choline. Nutrition and Cancer. Vol.14, No.3-4 (1990), 175-181. doi:10.1080/01635589009514092 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/15927
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Title
Inhibition of Hepatocarcinogenesis in Mice by Dietary Methyl Donors Methionine and Choline
Author(s)
Abstract
A dietary deficiency of methyl donors, the lipotropes methionine and choline, enhances the activity of hepatocarcinogens in rodents. To determine if the reverse is true, an excess of dietary choline, methionine, or both was fed to male mice given a carcinogenic dose of aflatoxin B1 (AFB1). Fifty weeks following the last dose of AFB1, all survivors were killed then examined for tumor incidence, and samples of nontumorous liver tissue were assayed for activities of mixed function oxidases (MFO). Survival was best in the high-methionine/high-choline group, with 36/38 surviving to termination of the study. Survival in the other groups was 35/38, 30/70, 33/38, and 34/37 in control with no AFB1, control with AFB1, groups with high methionine, and high choline, respectively. Combined adenoma/ carcinoma incidence was 8/38 30/37, 21/38, 20/37, and 10/38 in groups control with no AFB1, control with AFB1, high methione with AFB1, high choline with AFB1, and high choline and high methionine with AFB1, respectively. Cytochrome P450, cytochrome B5, cytochrome c, and ethylmorphine N-demethylase activities were all increased over controls, with most marked increases in the cytochrome P450 and ethylmorphine N-demethylase activities. The data presented here document a protective effect of dietary methyl donors on AFB1-induced hepatocarcinogenesis in mice probably acting, in part, via activation/ detoxification mechanisms favoring an increased balance in detoxification of AFB1. © 1990, Taylor & Francis Group, LLC. All rights reserved.