Publication: Plasmodium falciparum genetic crosses in a humanized mouse model
| dc.contributor.author | Ashley M. Vaughan | en_US |
| dc.contributor.author | Richard S. Pinapati | en_US |
| dc.contributor.author | Ian H. Cheeseman | en_US |
| dc.contributor.author | Nelly Camargo | en_US |
| dc.contributor.author | Matthew Fishbaugher | en_US |
| dc.contributor.author | Lisa A. Checkley | en_US |
| dc.contributor.author | Shalini Nair | en_US |
| dc.contributor.author | Carolyn A. Hutyra | en_US |
| dc.contributor.author | François H. Nosten | en_US |
| dc.contributor.author | Timothy J.C. Anderson | en_US |
| dc.contributor.author | Michael T. Ferdig | en_US |
| dc.contributor.author | Stefan H.I. Kappe | en_US |
| dc.contributor.other | Biomedical Research Institute | en_US |
| dc.contributor.other | University of Notre Dame | en_US |
| dc.contributor.other | Texas Biomedical Research Institute | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | University of Washington, Seattle | en_US |
| dc.date.accessioned | 2018-11-23T09:41:19Z | |
| dc.date.available | 2018-11-23T09:41:19Z | |
| dc.date.issued | 2015-06-30 | en_US |
| dc.description.abstract | © 2015 Nature America, Inc. All rights reserved. Genetic crosses of phenotypically distinct strains of the human malaria parasite Plasmodium falciparum are a powerful tool for identifying genes controlling drug resistance and other key phenotypes. Previous studies relied on the isolation of recombinant parasites from splenectomized chimpanzees, a research avenue that is no longer available. Here we demonstrate that human-liver chimeric mice support recovery of recombinant progeny for the identification of genetic determinants of parasite traits and adaptations. | en_US |
| dc.identifier.citation | Nature Methods. Vol.12, No.7 (2015), 631-633 | en_US |
| dc.identifier.doi | 10.1038/nmeth.3432 | en_US |
| dc.identifier.issn | 15487105 | en_US |
| dc.identifier.issn | 15487091 | en_US |
| dc.identifier.other | 2-s2.0-84934442316 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/35432 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84934442316&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.title | Plasmodium falciparum genetic crosses in a humanized mouse model | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84934442316&origin=inward | en_US |