Publication: Efficacy of 0.0125% capsaicin patch at acupuncture point for pain relief in knee osteoarthritis: A randomized controlled trial
Issued Date
2018-09-01
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22288082
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2-s2.0-85057544723
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Mahidol University
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SCOPUS
Bibliographic Citation
Siriraj Medical Journal. Vol.70, No.5 (2018), 382-390
Suggested Citation
Kamontip Harnphadungkit, Pravit Akarasereenont, Pranee Chadvongvan, Chayaporn Chotiyarnwong Efficacy of 0.0125% capsaicin patch at acupuncture point for pain relief in knee osteoarthritis: A randomized controlled trial. Siriraj Medical Journal. Vol.70, No.5 (2018), 382-390. doi:10.14456/smj.2018.61 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46359
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Title
Efficacy of 0.0125% capsaicin patch at acupuncture point for pain relief in knee osteoarthritis: A randomized controlled trial
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Abstract
© 2018 Siriraj Medical Journal. Objective: To study the efficacy of 0.0125% capsaicin patch at acupuncture point for pain relief in knee osteoarthritis (OA). Methods: This randomized, double-blind, placebo-controlled clinical trial was conducted during September 2014 to March 2015. Sixty-two ambulatory patients over 50 years of age with a diagnosis of knee OA were included. All enrolled patients had a pain score of 4-7 out of 10. Participants were randomized into either the treatment (capsaicin, n=31) or control (placebo, n=31) group. Interventions: Capsaicin vs. placebo patch at ST34 (1), SP10 (2), ST35 (3), EX-LE4 (Neixiyan) (4), ST36 (5), and SP9 (6) acupuncture points for 4 weeks. Main outcome measure: Pain subscale of modified Thai version of Western Ontario and McMaster (WOMAC) Osteoarthritis Index was assessed at baseline, 2, 4, 6, and 8 weeks after treatment. Results: Pain subscale of modified Thai version of WOMAC showed no significant difference between groups at baseline, 2, 4, 6, and 8 weeks after treatment. After 2 weeks of treatment, the pain subscale score in the treatment group was significantly decreased from baseline (p < 0.001). After 4 weeks of treatment, the pain subscale score in the placebo group was significantly decreased from baseline (p < 0.006). Conclusion: Capsaicin patch at acupuncture point for pain relief in knee OA yielded no significant difference between groups. However, significant pain relief from baseline was observed in the treatment group after 2 weeks of treatment and in the placebo group after 4 weeks of treatment. Further study with higher capsaicin concentration and/or larger size patch should be considered.