Publication: Antioxidant status and lipid peroxidation end products in patients of Type 1 diabetes mellitus
Issued Date
2006-11-01
Resource Type
ISSN
01252208
01252208
01252208
Other identifier(s)
2-s2.0-33846708854
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.89, No.SUPPL. 5 (2006)
Suggested Citation
Thavatchai Peerapatdit, Atip Likidlilid, Natchai Patchanans, Anchaleekorn Somkasetrin Antioxidant status and lipid peroxidation end products in patients of Type 1 diabetes mellitus. Journal of the Medical Association of Thailand. Vol.89, No.SUPPL. 5 (2006). Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23495
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Antioxidant status and lipid peroxidation end products in patients of Type 1 diabetes mellitus
Other Contributor(s)
Abstract
Background and Objective: In Type 1 diabetes mellitus (DM), hyperglycemia is considered a primary cause of diabetic vascular complications and is associated with oxidative stress. The role of antioxidants, particularly α tocopherol, in Type 1 DM and its contribution in the development of vascular complications is not clear. Therefore, the present study aims to investigate the relationship between antioxidant status (α tocopherol) and lipid peroxidation end products (malondialdehyde; MDA) in the plasma of 20 Type 1 DM and 20 nondiabetic healthy control subjects. Material and Method: Lipid levels in all subjects were analyzed spectrophotometrically by enzymatic reagent kits. Plasma MDA was assessed by spectrofluorometry, whereas plasma α tocopherol was estimated by high performance liquid chromatography in Type 1 DM as well as in the control subjects of matched sex and ages. The results of Type 1 DM were compared with a control group using unpaired Student's t-test. The correlations between fasting plasma glucose and other laboratory parameters were assessed by Pearson rank correlation coefficient. Results: The plasma MDA concentration was significantly higher in Type 1 diabetic patients as compared to controls, (p < 0.01). A significantly reduced plasma antioxidant status of Type 1 DM patients was found only in α tocopherol / total lipid as compared to controls (p < 0.05). However, no significant difference was observed in plasma α tocopherol and α tocopherol / total cholesterol (p < 0.05) as compared to the control subjects. The positive correlation between MDA and FPG was demonstrated in Type 1 diabetic compared with normal subjects. Conclusion: We conclude that antioxidant supplementation may be necessary for treatment to reduce oxidative stress for diabetic complication protection in Type 1 DM.