Publication: Multikinase Inhibitor-Induced Hand–Foot Skin Reaction: A Review of Clinical Presentation, Pathogenesis, and Management
Issued Date
2016-08-01
Resource Type
ISSN
11791888
11750561
11750561
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2-s2.0-84979708951
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Clinical Dermatology. Vol.17, No.4 (2016), 387-402
Suggested Citation
Kumutnart Chanprapaph, Suthinee Rutnin, Vasanop Vachiramon Multikinase Inhibitor-Induced Hand–Foot Skin Reaction: A Review of Clinical Presentation, Pathogenesis, and Management. American Journal of Clinical Dermatology. Vol.17, No.4 (2016), 387-402. doi:10.1007/s40257-016-0197-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41228
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Title
Multikinase Inhibitor-Induced Hand–Foot Skin Reaction: A Review of Clinical Presentation, Pathogenesis, and Management
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Abstract
© 2016, Springer International Publishing Switzerland. Multikinase inhibitors (MKIs) are targeted cancer therapies designed to inhibit multiple tyrosine kinase pathways responsible for tumor proliferation, growth, and survival. These agents are more able to target cancer cells and possess better safety profiles than conventional chemotherapies. However, MKIs can produce significant cutaneous adverse events, hand–foot skin reaction (HFSR) being the most clinically significant. Although not life threatening, HFSR can lead to MKI dose modification, interruption, or termination, potentially limiting the anti-tumor effect. This article summarizes the current knowledge concerning the epidemiology, clinical presentation, pathogenesis, histopathology, prognostic implication, and current evidence-based prophylactic and reactive treatment options for MKI-induced HFSR. Its high incidence and significant impact on the quality of life emphasizes the great need to understand the pathogenesis and improve management of this condition.