Publication: Clinical Classification, Screening and Diagnosis for Thalassemia
Issued Date
2018-04-01
Resource Type
ISSN
15581977
08898588
08898588
Other identifier(s)
2-s2.0-85042103908
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Mahidol University
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SCOPUS
Bibliographic Citation
Hematology/Oncology Clinics of North America. Vol.32, No.2 (2018), 193-211
Suggested Citation
Vip Viprakasit, Supachai Ekwattanakit Clinical Classification, Screening and Diagnosis for Thalassemia. Hematology/Oncology Clinics of North America. Vol.32, No.2 (2018), 193-211. doi:10.1016/j.hoc.2017.11.006 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46776
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Title
Clinical Classification, Screening and Diagnosis for Thalassemia
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Abstract
© 2017 Elsevier Inc. At present, thalassemia diseases are classified into transfusion-dependent thalassemia and non–transfusion-dependent thalassemia. This classification is based on the clinical severity of patients determining whether they do require regular blood transfusions to survive (transfusion-dependent thalassemia) or not (non–transfusion-dependent thalassemia). In addition to the previous terminology of “thalassemia major” or “thalassemia intermedia,” this classification has embraced all other forms of thalassemia syndromes such as α-thalassemia, hemoglobin E/β-thalassemia and combined α- and β-thalassemias. Definitive diagnosis of thalassemia and hemoglobinopathies requires a comprehensive workup from complete blood count, hemoglobin analysis, and molecular studies to identify mutations of globin genes.