Publication: Janus kinase 2 negative polycythemia vera
Issued Date
2015-10-01
Resource Type
ISSN
1875855X
19057415
19057415
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2-s2.0-84959357147
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Biomedicine. Vol.9, No.5 (2015), 697-700
Suggested Citation
Pravinwan Thungthong, Supat Chamnanchanunt, Tawatchai Suwanban, Chajchawan Nakhakes, Kunapa Iam-Arunthai Janus kinase 2 negative polycythemia vera. Asian Biomedicine. Vol.9, No.5 (2015), 697-700. doi:10.5372/1905-7415.0905.443 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35369
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Title
Janus kinase 2 negative polycythemia vera
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Abstract
Background: A Janus kinase 2 (JAK2) mutation polycythemia vera (PV) is a common manifestation of stem cell disorder. However, available data on the clinical and treatment response of JAK2-negative PV patients are limited. Objectives: We report the case and clinical course of a patient with PV and left hemiparesis who was JAK2V617- negative. Methods: We conducted a literature review and compared our patient with previously published reports of JAK2-negative patients with PV. Results: Our patient presented with hemiparesis without a previous history of hematological disease. He was diagnosed with PV based on the British Committee for Standards in Haematology guidelines 2007. He underwent only phlebotomy with subsequent improvement of his neurological condition. He was discharged with therapeutic phlebotomy for one and a half months. Conclusions: Although this rare condition required complex diagnostic criteria, the patient achieved good clinical outcome with therapeutic phlebotomy alone.