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Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregion

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dc.contributor.authorGermana Banconeen_US
dc.contributor.authorDidier Menarden_US
dc.contributor.authorNimol Khimen_US
dc.contributor.authorSaorin Kimen_US
dc.contributor.authorLydie Canieren_US
dc.contributor.authorChea Nguongen_US
dc.contributor.authorKoukeo Phommasoneen_US
dc.contributor.authorMayfong Mayxayen_US
dc.contributor.authorSabine Dittrichen_US
dc.contributor.authorMalavanh Vongsouvathen_US
dc.contributor.authorNadine Fieveten_US
dc.contributor.authorJean Yves Le Hesranen_US
dc.contributor.authorValerie Brianden_US
dc.contributor.authorSommay Keomanyen_US
dc.contributor.authorPaul N. Newtonen_US
dc.contributor.authorGornpan Gorsawunen_US
dc.contributor.authorKaelan Tardyen_US
dc.contributor.authorCindy S. Chuen_US
dc.contributor.authorOrpreeya Rattanapalrojen_US
dc.contributor.authorLe Thanh Dongen_US
dc.contributor.authorHuynh Hong Quangen_US
dc.contributor.authorNguyen Tam-Uyenen_US
dc.contributor.authorNguyen Thuy-Nhienen_US
dc.contributor.authorTran Tinh Hienen_US
dc.contributor.authorMichael Kalnokyen_US
dc.contributor.authorFrancois Nostenen_US
dc.contributor.otherFoundation for Innovative New Diagnostics, Switzerlanden_US
dc.contributor.otherInstitut Pasteur du Cambodgeen_US
dc.contributor.otherUniversite Paris Descartesen_US
dc.contributor.otherUCLen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherInstitut Pasteur, Parisen_US
dc.contributor.otherInstitute of Malariology Parasitology and Entomology - Quy Nhon (IMPE-QN)en_US
dc.contributor.otherLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU)en_US
dc.contributor.otherBureau of Vector Borne Diseasesen_US
dc.contributor.otherInstitute of Malariology-Parasitology and Entomology (IMPE)en_US
dc.contributor.otherNational Center for Parasitology, Entomology and Malaria Control (CNM)en_US
dc.contributor.otherPATHen_US
dc.contributor.otherSalavan Provincial Hospitalen_US
dc.contributor.otherUniversity of Health Sciencesen_US
dc.date.accessioned2020-01-27T09:01:41Z
dc.date.available2020-01-27T09:01:41Z
dc.date.issued2019-01-23en_US
dc.description.abstract© 2019 The Author(s). Background: Plasmodium vivax malaria elimination can only be achieved by the deployment of 8-aminoquinolines (primaquine and tafenoquine) in combination with ACT to kill both blood and liver-stage parasites. However, primaquine and the other 8-aminoquinolines cause dose-dependent haemolysis in subjects with G6PD deficiency, an X-linked disorder of red blood cells that is very common in populations living in tropical and subtropical areas. In order to inform safer use of 8-aminoquinolines in the Greater Mekong Subregion, a multi-centre study was carried out to assess the prevalence of G6PD deficiency and to identify the main G6PD variants in samples collected in Cambodia, Lao PDR, Myanmar, Thailand and Vietnam. Methods: Blood samples were collected in the five countries during National Malaria Surveys or during Population Surveys. During Population Surveys samples were characterized for G6PD phenotype using the Fluorescent Spot Test. Samples were then genotyped for a panel of G6PD mutations. Results: G6PD deficiency was found to be common in the region with an overall mean prevalence of deficient or mutated hemizygous males of 14.0%, ranging from a mean 7.3% in Thailand, 8.1% in Lao PDR, 8.9% in Vietnam, 15.8% in Myanmar and 18.8% in Cambodia. Mahidol and Viangchan mutations were the most common and widespread variants found among the nine investigated. Conclusions: Owing to the high prevalence of G6PD deficiency in the Greater Mekong Subregion, strategies for vivax malaria elimination should include point-of-care G6PD testing (both qualitative and quantitative) to allow safe and wide treatment with 8-aminoquinolines.en_US
dc.identifier.citationMalaria Journal. Vol.18, No.1 (2019)en_US
dc.identifier.doi10.1186/s12936-019-2652-yen_US
dc.identifier.issn14752875en_US
dc.identifier.other2-s2.0-85060396457en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14594/51111
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85060396457&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleMolecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregionen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85060396457&origin=inwarden_US
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