Publication:
Structural modification of oridonin: Via DAST induced rearrangement

Issued Date

2018-01-01

Resource Type

Article

ISSN

20462069

DOI

10.1039/c8ra05728a

Other identifier(s)

2-s2.0-85052630066

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

RSC Advances. Vol.8, No.52 (2018), 29548-29554

Suggested Citation

Dong Dong Luo, Kai Peng, Jia Yu Yang, Pawinee Piyachaturawat, Witchuda Saengsawang, Lei Ao, Wan Zhou Zhao, Yu Tang, Sheng Biao Wan Structural modification of oridonin: Via DAST induced rearrangement. RSC Advances. Vol.8, No.52 (2018), 29548-29554. doi:10.1039/c8ra05728a Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/45454

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Thesis

Title

Structural modification of oridonin: Via DAST induced rearrangement

Author(s)

Dong Dong Luo
 Kai Peng
 Jia Yu Yang
 Pawinee Piyachaturawat
 Witchuda Saengsawang
 Lei Ao
 Wan Zhou Zhao
 Yu Tang
 Sheng Biao Wan

Other Contributor(s)

Ocean University of China
 Mahidol University
 Nanjing OGpharma Co. Ltd.

Abstract

© 2018 The Royal Society of Chemistry. A simple and efficient protocol was developed for the syntheses of oridonin analogues, i.e. 6,20-epoxy ent-kaurane diterpenoid analogues from oridonin via diethylaminosulfur trifluoride (DAST) promoted rearrangement, most of which exhibited superior anticancer activities compared with their precursor.

Keyword(s)

Chemical Engineering
 Chemistry

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/45454

Collections

Scopus 2018