Publication: A comparison of artesunate alone with combined artesunate and quinine in the parenteral treatment of acute falciparum malaria
Issued Date
2001-01-01
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ISSN
00359203
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2-s2.0-0035467587
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Mahidol University
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SCOPUS
Bibliographic Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.95, No.5 (2001), 519-523
Suggested Citation
Paul N. Newton, Wirongrong Chierakul, Ronatrai Ruangveerayuth, Kamolrat Silamut, Pramote Teerapong, Srivicha Krudsood, Sornchai Looareesuwan, Nicholas J. White A comparison of artesunate alone with combined artesunate and quinine in the parenteral treatment of acute falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.95, No.5 (2001), 519-523. doi:10.1016/S0035-9203(01)90025-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26591
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Title
A comparison of artesunate alone with combined artesunate and quinine in the parenteral treatment of acute falciparum malaria
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Abstract
In some areas clinicians have combined parenteral artesunate and quinine in the belief that the 2 drugs would be additive or synergistic in severe malaria. A randomized comparison of the effectiveness of intravenous (iv) artesunate versus iv artesunate and iv quinine together on parasite clearance was conducted in 1998/99 amongst 69 patients with uncomplicated and severe Plasmodium falciparum malaria in western Thailand. The parasite clearance time did not differ significantly between the 2 treatment groups (P = 0.12), but adverse events were significantly more frequent in the artesunate plus quinine group (P = 0.05). Quinine did not have a significant antipyretic effect and artesunate did not affect the electrocardiographic QTc interval. There is no benefit evident from combining parenteral administration of these 2 antimalarial drugs in the acute phase of treatment. © 2002 OUP.