Publication: Development of pulsatile release tablets with swelling and rupturable layers
2
Issued Date
2004-03-05
Resource Type
ISSN
01683659
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2-s2.0-1242331818
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Controlled Release. Vol.95, No.2 (2004), 147-159
Suggested Citation
Srisagul Sungthongjeen, Satit Puttipipatkhachorn, Ornlaksana Paeratakul, Andrei Dashevsky, Roland Bodmeier Development of pulsatile release tablets with swelling and rupturable layers. Journal of Controlled Release. Vol.95, No.2 (2004), 147-159. doi:10.1016/j.jconrel.2003.10.023 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/21806
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Title
Development of pulsatile release tablets with swelling and rupturable layers
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Abstract
A tablet system consisting of cores coated with two layers of swelling and rupturable coatings was prepared and evaluated as pulsatile drug delivery system. Cores containing buflomedil HCl as model drug were prepared by direct compression of different ratios of spray-dried lactose and microcrystalline cellulose and were then coated sequentially with an inner swelling layer containing a superdisintegrant (croscarmellose sodium) and an outer rupturable layer of ethylcellulose. The effect of core composition, level of swelling layer and rupturable coating, and magnesium stearate in rupturable layer was investigated. Mechanical properties of ethylcellulose films in the dry and wet state were characterized with a puncture test. Rupture and dissolution tests were performed using the USP XXIV paddle method at 50 rpm in 0.1 N HCl. The lag time of the pulsatile release tablets decreased with increasing amount of microcrystalline cellulose in the cores and increased with increasing levels of both swelling layer and rupturable ethylcellulose coating. Increasing levels of the ethylcellulose coating retarded the water uptake and thus prolonged the lag time. Addition of magnesium stearate to the ethylcellulose coating lowered the mechanical strength of the film and improved the robustness of the system. © 2004 Elsevier B.V. All rights reserved.