Publication: Quantitation, absorption and tissue distribution of coenzyme q10 from pak-wanban (Sauropus androgynus L. Merr.) leaf and its antioxidant activities
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Issued Date
2021-01-01
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ISSN
2228835X
16863933
16863933
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2-s2.0-85099959577
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Mahidol University
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SCOPUS
Bibliographic Citation
Walailak Journal of Science and Technology. Vol.18, No.1 (2021), 1-10
Suggested Citation
Aikkarach Kettawan, Kansuda Wunjuntuk Quantitation, absorption and tissue distribution of coenzyme q10 from pak-wanban (Sauropus androgynus L. Merr.) leaf and its antioxidant activities. Walailak Journal of Science and Technology. Vol.18, No.1 (2021), 1-10. doi:10.48048/wjst.2021.6774 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/79413
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Quantitation, absorption and tissue distribution of coenzyme q10 from pak-wanban (Sauropus androgynus L. Merr.) leaf and its antioxidant activities
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Abstract
Pak-wanban (Sauropus androgynus L. Merr.), a popular Thai vegetable, has been found to have a high content of Coenzyme Q10 (CoQ10), which is a powerful antioxidant. This study investigated the quantitation, absorption and tissue distribution of CoQ10 from raw and stir-fried Pak-wanban and its antioxidant activities in rats. Male Wistar rats (seven weeks old) were randomly grouped as follows: (1) control, (2) raw Pak-wanban powder of 0.5 mg CoQ10/kg/day, (3) stir-fried Pak-wanban powder of 0.5 mg CoQ10/kg/day, (4) stir-fried Pak-wanban powder of 1.0 mg CoQ10/kg/day, and (5) commercially CoQ10 supplement groups of 0.5 mg CoQ10/kg/day. The results found that stir-fried cooking did not significantly reduce the content of CoQ10 in the Pak-wanban leaves. After 3 weeks of experimentation, the level of CoQ10 in the plasma, liver and spleen was increased in all Pak-wanban groups when compared to the control group. The level of CoQ10 in the stir-fried Pak-wanban group was significantly higher than the raw Pak-wanban group but slightly lower than the CoQ10 supplement group. Liver alpha-tocopherol concentrations were markedly increased in rats that consumed a high dose of CoQ10 from stir-fried Pak-wanban of 1 mg of CoQ10/kg/day when compared with the control group. Plasma antioxidant activities (ORAC: FRAP: DPPH) were significantly increased in both groups of stir-fried Pak-wanban when compared with the control group. We concluded that CoQ10 in Pak-wanban could be well absorbed and improved the plasma antioxidant activities. Furthermore, cooking oil may increase the bioavailability of CoQ10 from vegetables. Therefore, it would be useful for vegetarian people.