Publication: Epidemiology of sepsis in Siriraj Hospital 2007.
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Issued Date
2009-03-01
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ISSN
01252208
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2-s2.0-67651227304
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand = Chotmaihet thangphaet. Vol.92 Suppl 2, (2009)
Suggested Citation
Nasikarn Angkasekwinai, Pinyo Rattanaumpawan, Visanu Thamlikitkul Epidemiology of sepsis in Siriraj Hospital 2007.. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. Vol.92 Suppl 2, (2009). Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28147
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Title
Epidemiology of sepsis in Siriraj Hospital 2007.
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Abstract
BACKGROUND: Sepsis remains a major health burden, and there is limited epidemiological report of sepsis in Thailand. OBJECTIVE: To determine the epidemiology, treatments, clinical courses and outcomes of sepsis patients. MATERIAL AND METHOD: All sepsis patients in medical wards at Siriraj Hospital were recruited from February 1 to July 31, 2007. The information from patients' medical records were retrieved and analyzed. RESULTS: From 3,451 patients, 201 (5.8%) were diagnosed as sepsis, and 38.8% of these developed septic shock. Among sepsis patients, 62.2% were community acquired, 40.8% had bacteremia, and gram negative bacteria were the common pathogen (51.7%). Appropriate antibiotics were given within 6 hours in 39%. Goal-directed therapy was achieved in only 11.5%. The mortality among sepsis and septic shock patients was 34.3% and 52.6%, respectively (p = 0.008). Risk factors for hospital mortality included higher maximum SOFA score, hospital-acquired infection, central nervous system dysfunction and receiving antibiotics after 6 hours of onset of sepsis. CONCLUSION: Sepsis is still common and has contributed to high mortality. Goal directed therapy and appropriate antibiotics given within 6 hours might improve the outcome.