Publication: Comparison of point-of-care testing and hospital-based methods in screening for potential type 2 diabetes mellitus and abnormal glucose regulation in a dental setting
2
Issued Date
2021-06-02
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ISSN
16604601
16617827
16617827
Other identifier(s)
2-s2.0-85107888917
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Environmental Research and Public Health. Vol.18, No.12 (2021)
Suggested Citation
Muneedej Suwattipong, Thitima Thuramonwong, Chanita Tantipoj, Pornpoj Fuangtharnthip, Supanee Thanakun, Weerapan Khovidhunkit, Siribang On Piboonniyom Khovidhunkit Comparison of point-of-care testing and hospital-based methods in screening for potential type 2 diabetes mellitus and abnormal glucose regulation in a dental setting. International Journal of Environmental Research and Public Health. Vol.18, No.12 (2021). doi:10.3390/ijerph18126459 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/77037
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Title
Comparison of point-of-care testing and hospital-based methods in screening for potential type 2 diabetes mellitus and abnormal glucose regulation in a dental setting
Abstract
This study aimed to compare the screening methods between point-of-care (POC) testing and hospital-based methods for potential type 2 DM and abnormal glucose regulation (AGR) in a dental setting. A total of 274 consecutive subjects who attended the Faculty of Dentistry, Mahidol University, Bangkok, Thailand, were selected. Demographic data were collected. HbA1c was assessed using a finger prick blood sample and analyzed with a point-of-care (POC) testing machine (DCA Vantage® ). Hyperglycemia was defined as POC HbA1c ≥ 5.7%. Random blood glucose (RBG) was also evaluated using a glucometer (OneTouch® SelectSimple™) and hyperglycemia was defined as RBG ≥ 110 mg/dl or ≥140 mg/dl. The subjects were then sent for laboratory measurements for fasting plasma glucose (FPG) and HbA1c . The prevalence of AGR (defined as FPG ≥ 100 mg/dl or laboratory HbA1c ≥ 5.7%) and potential type 2 DM (defined as FPG ≥ 126 mg/dl or laboratory HbA1c ≥ 6.5%) among subjects was calculated and receiver operating characteristic (ROC) analysis was performed using FPG and HbA1c for the diagnosis of AGR and potential type 2 DM. The prevalence of hyperglycemia defined as POC HbA1c ≥ 5.7%, RBG ≥ 110 mg/dl, and RBG ≥ 140 mg/dl was 49%, 63%, and 32%, respectively. After the evaluation using laboratory measurements, the prevalence of AGR was 25% and 17% using laboratory FPG and HbA1c criteria, respectively. Based on the ROC curves, the performances of POC HbA1c and RBG in predicting FPG-defined potential type 2 DM were high (AUC = 0.99; 95% CI 0.98–0.99 and AUC = 0.94; 95% CI 0.86–1.0, respectively) but lower in predicting AGR (AUC = 0.72; 95% CI 0.67–0.78 and AUC = 0.65; 95% CI 0.59–0.70, respectively). This study suggested that POC testing might be a potential tool for screening of subjects with potential type 2 DM in a dental setting.